Lentiviral-Mediated shRNA Silencing of PDE4D Gene Inhibits Platelet-Derived Growth Factor-Induced Proliferation and Migration of Rat Aortic Smooth Muscle Cells
Joint Authors
Xu, Xiaowei
Sheng, Wenli
Li, Jiejie
Li, Xia
Liu, Lin
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-06-09
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Phosphodiesterase 4D (PDE4D) is a member of the large superfamily of phosphodiesterases.
PDE4D polymorphisms have been found to associate with ischemic stroke.
Proliferation and migration of vascular smooth muscle cells (VSMCs) play a critical role in the pathogenesis of atherosclerosis.
In this study, infection of VSMCs with lentivrius particles carrying shRNA direct against PDE4D significantly inhibited platelet-derived growth factor-induced VSMC proliferation and migration, and the inhibitory effects were not associated with global intracellular cAMP level.
Our results implicate that PDE4D has an important role in VSMC proliferation and migration which may explain its genetic susceptibility to ischemic stroke.
American Psychological Association (APA)
Liu, Lin& Xu, Xiaowei& Li, Jiejie& Li, Xia& Sheng, Wenli. 2011. Lentiviral-Mediated shRNA Silencing of PDE4D Gene Inhibits Platelet-Derived Growth Factor-Induced Proliferation and Migration of Rat Aortic Smooth Muscle Cells. Stroke Research and Treatment،Vol. 2011, no. 2011, pp.1-7.
https://search.emarefa.net/detail/BIM-479345
Modern Language Association (MLA)
Liu, Lin…[et al.]. Lentiviral-Mediated shRNA Silencing of PDE4D Gene Inhibits Platelet-Derived Growth Factor-Induced Proliferation and Migration of Rat Aortic Smooth Muscle Cells. Stroke Research and Treatment No. 2011 (2011), pp.1-7.
https://search.emarefa.net/detail/BIM-479345
American Medical Association (AMA)
Liu, Lin& Xu, Xiaowei& Li, Jiejie& Li, Xia& Sheng, Wenli. Lentiviral-Mediated shRNA Silencing of PDE4D Gene Inhibits Platelet-Derived Growth Factor-Induced Proliferation and Migration of Rat Aortic Smooth Muscle Cells. Stroke Research and Treatment. 2011. Vol. 2011, no. 2011, pp.1-7.
https://search.emarefa.net/detail/BIM-479345
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-479345
