Serum β-Catenin Levels Associated with the Ratio of RANKLOPG in Patients with Postmenopausal Osteoporosis
Joint Authors
Li, Cheng-Gang
Shen, Lin
Yang, Yan-Ping
Wu, Man-Xiang
Shuai, Bo
Zhu, Rui
Xu, Xiao-Juan
Source
International Journal of Endocrinology
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-04-22
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Objective.
To demonstrate the role of Wnt/β-catenin canonical pathway in postmenopausal osteoporosis by evaluating serum β-catenin levels in patients with postmenopausal osteoporosis and analyzing their possible relationship with serum OPG, RANKL, the ratio of RANKL/OPG, sclerostin, and bone turnover markers.
Methods.
480 patients with postmenopausal osteoporosis and 170 healthy postmenopausal women were enrolled in the study.
Serum β-catenin, OPG, RANKL, and sclerostin levels were measured by enzyme-linked immunosorbent assay.
Bone status was assessed by measuring bone mineral density and bone turnover markers.
Estradiol levels were also detected.
Results.
Serum β-catenin levels were lower in postmenopausal osteoporotic women compared to nonosteoporotic postmenopausal women (26.26±14.81 versus 39.33±5.47 pg/mL, P<0.001).
Serum β-catenin was positively correlated with osteoprotegerin (r=0.232, P<0.001) and negatively correlated with the ratio of RANKL/OPG, body mass index, and sclerostin (r=-0.128, P=0.005; r=-0.117, P=0.010; r=-0.400, P<0.001, resp.) in patients with postmenopausal osteoporosis.
Conclusion.
The results indicate that lower serum β-catenin and concomitantly higher ratio of RANKL/OPG may be involved in the pathogenesis of postmenopausal osteoporosis.
Functional communication between RANKL/RANK/OPG system and Wnt pathways plays an important role in postmenopausal osteoporosis.
American Psychological Association (APA)
Xu, Xiao-Juan& Shen, Lin& Yang, Yan-Ping& Zhu, Rui& Shuai, Bo& Li, Cheng-Gang…[et al.]. 2013. Serum β-Catenin Levels Associated with the Ratio of RANKLOPG in Patients with Postmenopausal Osteoporosis. International Journal of Endocrinology،Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-479357
Modern Language Association (MLA)
Xu, Xiao-Juan…[et al.]. Serum β-Catenin Levels Associated with the Ratio of RANKLOPG in Patients with Postmenopausal Osteoporosis. International Journal of Endocrinology No. 2013 (2013), pp.1-7.
https://search.emarefa.net/detail/BIM-479357
American Medical Association (AMA)
Xu, Xiao-Juan& Shen, Lin& Yang, Yan-Ping& Zhu, Rui& Shuai, Bo& Li, Cheng-Gang…[et al.]. Serum β-Catenin Levels Associated with the Ratio of RANKLOPG in Patients with Postmenopausal Osteoporosis. International Journal of Endocrinology. 2013. Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-479357
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-479357