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Toll-Like Receptors and Cytokines as Surrogate Biomarkers for Evaluating Vaginal Immune Response following Microbicide Administration
Joint Authors
Gupta, Sadhana M.
Reddy, K. V. R.
Aranha, Clara C.
Mohanty, Madhu C.
Source
Issue
Vol. 2008, Issue 2008 (31 Dec. 2008), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2008-12-22
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Topical microbicides are intended for frequent use by women in reproductive age.
Hence, it is essential to evaluate their impact on mucosal immune function in the vagina.
In the present study, we evaluated nisin, a naturally occurring antimicrobial peptide (AMP), for its efficacy as an intravaginal microbicide.
Its effect on the vaginal immune function was determined by localizing Toll-like receptors (TLRs-3, 9) and cytokines (IL-4, 6 , 10 and TNF-α) in the rabbit cervicovaginal epithelium following intravaginal administration of high dose of nisin gel for 14 consecutive days.
The results revealed no alteration in the expression of TLRs and cytokines at both protein and mRNA levels.
However, in SDS gel-treated group, the levels were significantly upregulated with the induction of NF-κB signalling cascade.
Thus, TLRs and cytokines appear as sensitive indicators for screening immunotoxic potential of candidate microbicides.
American Psychological Association (APA)
Gupta, Sadhana M.& Aranha, Clara C.& Mohanty, Madhu C.& Reddy, K. V. R.. 2008. Toll-Like Receptors and Cytokines as Surrogate Biomarkers for Evaluating Vaginal Immune Response following Microbicide Administration. Mediators of Inflammation،Vol. 2008, no. 2008, pp.1-11.
https://search.emarefa.net/detail/BIM-479368
Modern Language Association (MLA)
Gupta, Sadhana M.…[et al.]. Toll-Like Receptors and Cytokines as Surrogate Biomarkers for Evaluating Vaginal Immune Response following Microbicide Administration. Mediators of Inflammation No. 2008 (2008), pp.1-11.
https://search.emarefa.net/detail/BIM-479368
American Medical Association (AMA)
Gupta, Sadhana M.& Aranha, Clara C.& Mohanty, Madhu C.& Reddy, K. V. R.. Toll-Like Receptors and Cytokines as Surrogate Biomarkers for Evaluating Vaginal Immune Response following Microbicide Administration. Mediators of Inflammation. 2008. Vol. 2008, no. 2008, pp.1-11.
https://search.emarefa.net/detail/BIM-479368
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-479368