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Acute Disruption of Bone Marrow B Lymphopoiesis and Apoptosis of Transitional and Marginal Zone B Cells in the Spleen following a Blood-Stage Plasmodium chabaudi Infection in Mice
Joint Authors
Bockstal, Viki
Magez, Stefan
Geurts, Nathalie
Source
Journal of Parasitology Research
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-05-04
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
B cells and antibodies are essential for the protective immune response against a blood-stage Plasmodium infection.
Although extensive research has focused on memory as well as plasma B-cell responses during infection, little is known about how malaria affects B-cell development and splenic maturation into marginal zone B (MZB) and follicular B (FoB) cells.
In this study, we show that acute Plasmodium chabaudi AS infection in C57Bl/6 mice causes severe disruption of B lymphopoiesis in the bone marrow, affecting in particular pro-, pre-, and immature B cells as well as the expression of the bone marrow B-cell retention chemokine CXCL12.
In addition, elevated apoptosis of transitional T2 and marginal zone (MZ) B cells was observed during and subsequent to the control of the first wave of parasitemia.
In contrast, Folllicular (Fo) B cells levels were retained in the spleen throughout the infection, suggesting that these are essential for parasite clearance and proper infection control.
American Psychological Association (APA)
Bockstal, Viki& Geurts, Nathalie& Magez, Stefan. 2011. Acute Disruption of Bone Marrow B Lymphopoiesis and Apoptosis of Transitional and Marginal Zone B Cells in the Spleen following a Blood-Stage Plasmodium chabaudi Infection in Mice. Journal of Parasitology Research،Vol. 2011, no. 2011, pp.1-11.
https://search.emarefa.net/detail/BIM-479384
Modern Language Association (MLA)
Bockstal, Viki…[et al.]. Acute Disruption of Bone Marrow B Lymphopoiesis and Apoptosis of Transitional and Marginal Zone B Cells in the Spleen following a Blood-Stage Plasmodium chabaudi Infection in Mice. Journal of Parasitology Research No. 2011 (2011), pp.1-11.
https://search.emarefa.net/detail/BIM-479384
American Medical Association (AMA)
Bockstal, Viki& Geurts, Nathalie& Magez, Stefan. Acute Disruption of Bone Marrow B Lymphopoiesis and Apoptosis of Transitional and Marginal Zone B Cells in the Spleen following a Blood-Stage Plasmodium chabaudi Infection in Mice. Journal of Parasitology Research. 2011. Vol. 2011, no. 2011, pp.1-11.
https://search.emarefa.net/detail/BIM-479384
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-479384