Intervention in Biological Phenomena via Feedback Linearization
Joint Authors
Nounou, Hazem N.
Datta, Aniruddha
Fnaiech, Mohamed Amine
Nounou, Mohamed N.
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-11-06
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Biology
Abstract EN
The problems of modeling and intervention of biological phenomena have captured the interest of many researchers in the past few decades.
The aim of the therapeutic intervention strategies is to move an undesirable state of a diseased network towards a more desirable one.
Such an objective can be achieved by the application of drugs to act on some genes/metabolites that experience the undesirable behavior.
For the purpose of design and analysis of intervention strategies, mathematical models that can capture the complex dynamics of the biological systems are needed.
S-systems, which offer a good compromise between accuracy and mathematical flexibility, are a promising framework for modeling the dynamical behavior of biological phenomena.
Due to the complex nonlinear dynamics of the biological phenomena represented by S-systems, nonlinear intervention schemes are needed to cope with the complexity of the nonlinear S-system models.
Here, we present an intervention technique based on feedback linearization for biological phenomena modeled by S-systems.
This technique is based on perfect knowledge of the S-system model.
The proposed intervention technique is applied to the glycolytic-glycogenolytic pathway, and simulation results presented demonstrate the effectiveness of the proposed technique.
American Psychological Association (APA)
Fnaiech, Mohamed Amine& Nounou, Hazem N.& Nounou, Mohamed N.& Datta, Aniruddha. 2012. Intervention in Biological Phenomena via Feedback Linearization. Advances in Bioinformatics،Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-479393
Modern Language Association (MLA)
Fnaiech, Mohamed Amine…[et al.]. Intervention in Biological Phenomena via Feedback Linearization. Advances in Bioinformatics No. 2012 (2012), pp.1-9.
https://search.emarefa.net/detail/BIM-479393
American Medical Association (AMA)
Fnaiech, Mohamed Amine& Nounou, Hazem N.& Nounou, Mohamed N.& Datta, Aniruddha. Intervention in Biological Phenomena via Feedback Linearization. Advances in Bioinformatics. 2012. Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-479393
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-479393