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Systemic Administration of Mesenchymal Stem Cells Increases Neuron Survival after Global Cerebral Ischemia In Vivo (2VO)
Joint Authors
Giunti, Debora
Ruggeri, Piero
Cogo, Carla Emilia
Balestrino, Maurizio
Gandolfo, Carlo
Perasso, Luisa
Uccelli, Antonio
Source
Issue
Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-12-19
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Although many studies have shown that administration of stem cells after focal cerebral ischemia improves brain damage, very little data are available concerning the damage induced by global cerebral ischemia.
The latter causes neuronal death in selectively vulnerable areas, including the hippocampal CA1 region.
We tested the hypothesis that intravenous infusion of bone marrowderived stromal cells (mesenchimal stem cells, MSC) reduce brain damage after transient global ischemia.
In adult male Sprague-Dawley rats transient global ischemia was induced using bilateral common carotid artery occlusion for 20 min in addition to controlled hypotension.
Five days after, the animals were anaesthetized with urethane and the brain was fixed, sectioned and stained with hematoxylin-eosin to investigate histological damage.
MSC did not fully protect against ischemic damage, as the number of viable neurons in this group was lower than in normal (sham-operated) rats.
However, in MSC-treated rats the number of viable CA1 pyramidal neurons was significally higher than in rats that had been subjected to ischemia but not treated with MSC.
We conclude that intravenous administration of MSC after transient global ischemia reduces hippocampal damage.
American Psychological Association (APA)
Perasso, Luisa& Cogo, Carla Emilia& Giunti, Debora& Gandolfo, Carlo& Ruggeri, Piero& Uccelli, Antonio…[et al.]. 2010. Systemic Administration of Mesenchymal Stem Cells Increases Neuron Survival after Global Cerebral Ischemia In Vivo (2VO). Neural Plasticity،Vol. 2010, no. 2010, pp.1-5.
https://search.emarefa.net/detail/BIM-479400
Modern Language Association (MLA)
Perasso, Luisa…[et al.]. Systemic Administration of Mesenchymal Stem Cells Increases Neuron Survival after Global Cerebral Ischemia In Vivo (2VO). Neural Plasticity No. 2010 (2010), pp.1-5.
https://search.emarefa.net/detail/BIM-479400
American Medical Association (AMA)
Perasso, Luisa& Cogo, Carla Emilia& Giunti, Debora& Gandolfo, Carlo& Ruggeri, Piero& Uccelli, Antonio…[et al.]. Systemic Administration of Mesenchymal Stem Cells Increases Neuron Survival after Global Cerebral Ischemia In Vivo (2VO). Neural Plasticity. 2010. Vol. 2010, no. 2010, pp.1-5.
https://search.emarefa.net/detail/BIM-479400
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-479400