Comprehensive Evaluation of Different T-Helper Cell Subsets Differentiation and Function in Rheumatoid Arthritis
Joint Authors
Gao, Huiying
Luo, Jing
Chen, Junwei
Li, Xiaofeng
Li, Junxia
Lv, Zhiqin
Wang, Caihong
Source
Journal of Biomedicine and Biotechnology
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-10-03
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Rheumatoid arthritis (RA) is the most common autoimmune disorder.
Loss of Th1/Th2 and Th17/Treg balance has been reported in several inflammatory autoimmune diseases.
This study was to investigate Th1, Th2, Th17, and Treg differentiation and related cytokines in RA patients.
The frequencies of Th1, Th2, Th17, and Treg cells in peripheral blood of RA patients (n=76) and healthy controls (n=18) were determined by flow cytometry.
Eight serum cytokines were analyzed using cytometric bead array.
The results demonstrated that RA patients exhibited increased peripheral Th1/Th17 cells and Th1/Th17-related cytokines.
However, Th1 cells only reached significant difference at advanced stage, but Th17 at all stages, suggesting more important roles in Th17 cells.
For Th2 and Treg cells, there was a different function pattern in RA progression.
Although with the increase of DAS28 score, Th2 cell experienced some degree of decrease in RA patients, no significant difference was observed.
IL-4 and IL-10 showed a significant increase in RA patients.
These indicated that Th2 cells might exert immunosuppression effects mainly by secreting cytokines.
Treg cells were found significantly decreased in RA patients, but no difference was observed in TGF-β expression, indicating a cell-cell interaction pattern in Treg cell.
American Psychological Association (APA)
Chen, Junwei& Li, Junxia& Gao, Huiying& Wang, Caihong& Luo, Jing& Lv, Zhiqin…[et al.]. 2012. Comprehensive Evaluation of Different T-Helper Cell Subsets Differentiation and Function in Rheumatoid Arthritis. Journal of Biomedicine and Biotechnology،Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-479432
Modern Language Association (MLA)
Chen, Junwei…[et al.]. Comprehensive Evaluation of Different T-Helper Cell Subsets Differentiation and Function in Rheumatoid Arthritis. Journal of Biomedicine and Biotechnology No. 2012 (2012), pp.1-6.
https://search.emarefa.net/detail/BIM-479432
American Medical Association (AMA)
Chen, Junwei& Li, Junxia& Gao, Huiying& Wang, Caihong& Luo, Jing& Lv, Zhiqin…[et al.]. Comprehensive Evaluation of Different T-Helper Cell Subsets Differentiation and Function in Rheumatoid Arthritis. Journal of Biomedicine and Biotechnology. 2012. Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-479432
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-479432