JAK2 Inhibition : Reviewing a New Therapeutical Option in Myeloproliferative Neoplasms
Joint Authors
te Boekhorst, Peter A. W.
Bellido, Mar
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-02-16
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
JAK2 is a tyrosine kinase gene that plays an essential role in the development of normal haematopoiesis.
Hyperactivation of JAK2 occurs in myeloproliferative neoplasms by different mechanisms.
As a consequence, JAK2 inhibitors have been designed to suppress the cytokine signalling cascade caused by the constitutive activation of JAK2.
In clinical trials, JAK2 inhibitors are efficient in decreasing spleen size, controlling clinical symptoms, and improving quality of life in patients with myeloproliferative neoplasms.
However, JAK2 inhibitors are unable to target uncommitted hematopoietic progenitors responsible of the initiation of the myeloproliferative disease.
It is expected that, in order to cure the myeloproliferative disease, JAK2 inhibitors should be combined with other drugs to target simultaneously different pathways and to target the initiator hematopoietic cell population in myeloproliferative disorders.
Taking advantage of the inhibition of the cytokine cascade of JAK2 inhibitors, these compounds are going to be used not only to treat patients with hematological neoplasms but may also be beneficial to treat patients with rheumatoid arthritis or other inflammatory diseases.
American Psychological Association (APA)
Bellido, Mar& te Boekhorst, Peter A. W.. 2012. JAK2 Inhibition : Reviewing a New Therapeutical Option in Myeloproliferative Neoplasms. Advances in Hematology،Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-479447
Modern Language Association (MLA)
Bellido, Mar& te Boekhorst, Peter A. W.. JAK2 Inhibition : Reviewing a New Therapeutical Option in Myeloproliferative Neoplasms. Advances in Hematology No. 2012 (2012), pp.1-6.
https://search.emarefa.net/detail/BIM-479447
American Medical Association (AMA)
Bellido, Mar& te Boekhorst, Peter A. W.. JAK2 Inhibition : Reviewing a New Therapeutical Option in Myeloproliferative Neoplasms. Advances in Hematology. 2012. Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-479447
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-479447