Epstein-Barr Virus in Systemic Autoimmune Diseases

Joint Authors

Duus, Karen
Draborg, Anette Holck
Houen, Gunnar

Source

Clinical and Developmental Immunology

Issue

Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-9, 9 p.

Publisher

Hindawi Publishing Corporation

Publication Date

2013-08-24

Country of Publication

Egypt

No. of Pages

9

Main Subjects

Biology

Abstract EN

Systemic autoimmune diseases (SADs) are a group of connective tissue diseases with diverse, yet overlapping, symptoms and autoantibody development.

The etiology behind SADs is not fully elucidated, but a number of genetic and environmental factors are known to influence the incidence of SADs.

Recent findings link dysregulation of Epstein-Barr virus (EBV) with SAD development.

EBV causes a persistent infection with a tight latency programme in memory B-cells, which enables evasion of the immune defence.

A number of immune escape mechanisms and immune-modulating proteins have been described for EBV.

These immune modulating functions make EBV a good candidate for initiation of autoimmune diseases and exacerbation of disease progression.

This review focuses on systemic lupus erythematosus (SLE), rheumatoid arthritis (RA), and Sjögren’s syndrome (SS) and sum up the existing data linking EBV with these diseases including elevated titres of EBV antibodies, reduced T-cell defence against EBV, and elevated EBV viral load.

Together, these data suggest that uncontrolled EBV infection can develop diverse autoreactivities in genetic susceptible individuals with different manifestations depending on the genetic background and the site of reactivation.

American Psychological Association (APA)

Draborg, Anette Holck& Duus, Karen& Houen, Gunnar. 2013. Epstein-Barr Virus in Systemic Autoimmune Diseases. Clinical and Developmental Immunology،Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-479450

Modern Language Association (MLA)

Draborg, Anette Holck…[et al.]. Epstein-Barr Virus in Systemic Autoimmune Diseases. Clinical and Developmental Immunology No. 2013 (2013), pp.1-9.
https://search.emarefa.net/detail/BIM-479450

American Medical Association (AMA)

Draborg, Anette Holck& Duus, Karen& Houen, Gunnar. Epstein-Barr Virus in Systemic Autoimmune Diseases. Clinical and Developmental Immunology. 2013. Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-479450

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references

Record ID

BIM-479450