The Default Mode Network in Healthy Aging and Alzheimer's Disease

Joint Authors

Eustache, Francis
Desgranges, Béatrice
Mevel, Katell
Chételat, Gaël

Source

International Journal of Alzheimer's Disease

Issue

Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-9, 9 p.

Publisher

Hindawi Publishing Corporation

Publication Date

2011-06-14

Country of Publication

Egypt

No. of Pages

9

Main Subjects

Diseases
Medicine

Abstract EN

In the past decade, a “default mode network” (DMN) has been highlighted in neuroimaging studies as a set of brain regions showing increased activity in task-free state compared to cognitively demanding task, and synchronized activity at rest.

Changes within this network have been described in healthy aging as well as in Alzheimer's disease (AD) and populations at risk for AD, that is, amnestic Mild Cognitive Impairment (aMCI) patients and APOE-ε4 carriers.

This is of particular interest in the context of early diagnosis and more generally for our understanding of the physiopathological mechanisms of AD.

This paper gives an overview of the anatomical and physiological characteristics of this network as well as its relationships with cognition, before focusing on changes in the DMN over normal aging and Alzheimer's disease.

While perturbations of the DMN have been consistently reported, especially within the posterior cingulate, further studies are needed to understand their clinical implication.

American Psychological Association (APA)

Mevel, Katell& Chételat, Gaël& Eustache, Francis& Desgranges, Béatrice. 2011. The Default Mode Network in Healthy Aging and Alzheimer's Disease. International Journal of Alzheimer's Disease،Vol. 2011, no. 2011, pp.1-9.
https://search.emarefa.net/detail/BIM-479460

Modern Language Association (MLA)

Mevel, Katell…[et al.]. The Default Mode Network in Healthy Aging and Alzheimer's Disease. International Journal of Alzheimer's Disease No. 2011 (2011), pp.1-9.
https://search.emarefa.net/detail/BIM-479460

American Medical Association (AMA)

Mevel, Katell& Chételat, Gaël& Eustache, Francis& Desgranges, Béatrice. The Default Mode Network in Healthy Aging and Alzheimer's Disease. International Journal of Alzheimer's Disease. 2011. Vol. 2011, no. 2011, pp.1-9.
https://search.emarefa.net/detail/BIM-479460

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references

Record ID

BIM-479460