The Default Mode Network in Healthy Aging and Alzheimer's Disease
Joint Authors
Eustache, Francis
Desgranges, Béatrice
Mevel, Katell
Chételat, Gaël
Source
International Journal of Alzheimer's Disease
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-06-14
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
In the past decade, a “default mode network” (DMN) has been highlighted in neuroimaging studies as a set of brain regions showing increased activity in task-free state compared to cognitively demanding task, and synchronized activity at rest.
Changes within this network have been described in healthy aging as well as in Alzheimer's disease (AD) and populations at risk for AD, that is, amnestic Mild Cognitive Impairment (aMCI) patients and APOE-ε4 carriers.
This is of particular interest in the context of early diagnosis and more generally for our understanding of the physiopathological mechanisms of AD.
This paper gives an overview of the anatomical and physiological characteristics of this network as well as its relationships with cognition, before focusing on changes in the DMN over normal aging and Alzheimer's disease.
While perturbations of the DMN have been consistently reported, especially within the posterior cingulate, further studies are needed to understand their clinical implication.
American Psychological Association (APA)
Mevel, Katell& Chételat, Gaël& Eustache, Francis& Desgranges, Béatrice. 2011. The Default Mode Network in Healthy Aging and Alzheimer's Disease. International Journal of Alzheimer's Disease،Vol. 2011, no. 2011, pp.1-9.
https://search.emarefa.net/detail/BIM-479460
Modern Language Association (MLA)
Mevel, Katell…[et al.]. The Default Mode Network in Healthy Aging and Alzheimer's Disease. International Journal of Alzheimer's Disease No. 2011 (2011), pp.1-9.
https://search.emarefa.net/detail/BIM-479460
American Medical Association (AMA)
Mevel, Katell& Chételat, Gaël& Eustache, Francis& Desgranges, Béatrice. The Default Mode Network in Healthy Aging and Alzheimer's Disease. International Journal of Alzheimer's Disease. 2011. Vol. 2011, no. 2011, pp.1-9.
https://search.emarefa.net/detail/BIM-479460
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-479460