The Development and the Use of Experimental Animal Models to Study the Underlying Mechanisms of CA Formation
Joint Authors
Nishimura, Masaki
Aoki, Tomohiro
Source
Journal of Biomedicine and Biotechnology
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-12-28
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Cerebral aneurysms (CAs) have a high prevalence and can cause a lethal subarachnoid hemorrhage.
Currently, CAs can only be treated with invasive surgical procedures.
To unravel the underlying mechanisms of CA formation and to develop new therapeutic drugs for CAs, animal models of CA have been established, modified, and analyzed.
Experimental findings from these models have clarified some of the potential mechanisms of CA formation, especially the relationship between hemodynamic stress and chronic inflammation.
Increased hemodynamic stress acting at the site of bifurcation of cerebral arteries triggers an inflammatory response mediated by various proinflammatory molecules in arterial walls, inducing pathological changes in the models similar to those observed in the walls of human CAs.
Findings from animal studies have provided new insights into CA formation and may contribute to the development of new therapeutic drugs for CAs.
American Psychological Association (APA)
Aoki, Tomohiro& Nishimura, Masaki. 2010. The Development and the Use of Experimental Animal Models to Study the Underlying Mechanisms of CA Formation. Journal of Biomedicine and Biotechnology،Vol. 2011, no. 2011, pp.1-10.
https://search.emarefa.net/detail/BIM-479471
Modern Language Association (MLA)
Aoki, Tomohiro& Nishimura, Masaki. The Development and the Use of Experimental Animal Models to Study the Underlying Mechanisms of CA Formation. Journal of Biomedicine and Biotechnology No. 2011 (2011), pp.1-10.
https://search.emarefa.net/detail/BIM-479471
American Medical Association (AMA)
Aoki, Tomohiro& Nishimura, Masaki. The Development and the Use of Experimental Animal Models to Study the Underlying Mechanisms of CA Formation. Journal of Biomedicine and Biotechnology. 2010. Vol. 2011, no. 2011, pp.1-10.
https://search.emarefa.net/detail/BIM-479471
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-479471