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The Effect of the Thioether-Bridged, Stabilized Angiotensin-(1–7) Analogue Cyclic Ang-(1–7) on Cardiac Remodeling and Endothelial Function in Rats with Myocardial Infarction
Joint Authors
Rink, Rick
Haas Jimoh Akanbi, Marijke
Durik, Matej
Kuipers, Anneke
Moll, Gert
van Veghel, Richard
Roks, Anton J. M.
Danser, A. H. Jan
Source
International Journal of Hypertension
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-10-29
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Modulation of renin-angiotensin system (RAS) by angiotensin-(1–7) (Ang-(1–7)) is an attractive approach to combat the detrimental consequences of myocardial infarction (MI).
However Ang-(1–7) has limited clinical potential due to its unfavorable pharmacokinetic profile.
We investigated effects of a stabilized, thioether-bridged analogue of Ang-(1–7) called cyclic Ang-(1–7) in rat model of myocardial infarction.
Rats underwent coronary ligation or sham surgery.
Two weeks thereafter infusion with 0.24 or 2.4 μg/kg/h cAng-(1–7) or saline was started for 8 weeks.
Thereafter, cardiac morphometric and hemodynamic variables as wells as aortic endothelial function were measured.
The average infarct size was 13.8% and was not changed by cAng-(1–7) treatment.
MI increased heart weight and myocyte size, which was restored by cAng-(1–7) to sham levels.
In addition, cAng-(1–7) lowered left ventricular end-diastolic pressure and improved endothelial function.
The results suggest that cAng-(1–7) is a promising new agent in treatment of myocardial infarction and warrant further research.
American Psychological Association (APA)
Durik, Matej& van Veghel, Richard& Kuipers, Anneke& Rink, Rick& Haas Jimoh Akanbi, Marijke& Moll, Gert…[et al.]. 2011. The Effect of the Thioether-Bridged, Stabilized Angiotensin-(1–7) Analogue Cyclic Ang-(1–7) on Cardiac Remodeling and Endothelial Function in Rats with Myocardial Infarction. International Journal of Hypertension،Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-479523
Modern Language Association (MLA)
Durik, Matej…[et al.]. The Effect of the Thioether-Bridged, Stabilized Angiotensin-(1–7) Analogue Cyclic Ang-(1–7) on Cardiac Remodeling and Endothelial Function in Rats with Myocardial Infarction. International Journal of Hypertension No. 2012 (2012), pp.1-8.
https://search.emarefa.net/detail/BIM-479523
American Medical Association (AMA)
Durik, Matej& van Veghel, Richard& Kuipers, Anneke& Rink, Rick& Haas Jimoh Akanbi, Marijke& Moll, Gert…[et al.]. The Effect of the Thioether-Bridged, Stabilized Angiotensin-(1–7) Analogue Cyclic Ang-(1–7) on Cardiac Remodeling and Endothelial Function in Rats with Myocardial Infarction. International Journal of Hypertension. 2011. Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-479523
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-479523