Bipolar Disorder and Multiple Sclerosis : A Case Series

Joint Authors

Ben Djebara, Mouna
Abdelkefi, Istabrak
Sidhom, Youssef
Hizem, Yosr
Kacem, Imen
Gargouri, Amina
Gouider, Riadh

Source

Behavioural Neurology

Issue

Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-4, 4 p.

Publisher

Hindawi Publishing Corporation

Publication Date

2014-03-17

Country of Publication

Egypt

No. of Pages

4

Main Subjects

Biology
Medicine

Abstract EN

Background.

The prevalence of psychiatric disturbance for patients with multiple sclerosis (MS) is higher than that observed in other chronic health conditions.

We report three cases of MS and bipolar disorder and we discuss the possible etiological hypothesis and treatment options.

Observations.

All patients fulfilled the McDonald criteria for MS.

Two patients were followed up in psychiatry for manic or depressive symptoms before developing MS.

A third patient was diagnosed with MS and developed deferred psychotic symptoms.

Some clinical and radiological features are highlighted in our patients: one manic episode induced by high dose corticosteroids and one case of a new orbitofrontal MRI lesion concomitant with the emergence of psychiatric symptoms.

All patients needed antipsychotic treatment with almost good tolerance for high dose corticosteroids and interferon beta treatment.

Conclusions.

MRI lesions suggest the possible implication of local MS-related brain damage in development of pure “psychiatric fits” in MS.

Genetic susceptibility is another hypothesis for this association.

We have noticed that interferon beta treatments were well tolerated while high dose corticosteroids may induce manic fits.

American Psychological Association (APA)

Sidhom, Youssef& Ben Djebara, Mouna& Hizem, Yosr& Abdelkefi, Istabrak& Kacem, Imen& Gargouri, Amina…[et al.]. 2014. Bipolar Disorder and Multiple Sclerosis : A Case Series. Behavioural Neurology،Vol. 2014, no. 2014, pp.1-4.
https://search.emarefa.net/detail/BIM-479534

Modern Language Association (MLA)

Sidhom, Youssef…[et al.]. Bipolar Disorder and Multiple Sclerosis : A Case Series. Behavioural Neurology No. 2014 (2014), pp.1-4.
https://search.emarefa.net/detail/BIM-479534

American Medical Association (AMA)

Sidhom, Youssef& Ben Djebara, Mouna& Hizem, Yosr& Abdelkefi, Istabrak& Kacem, Imen& Gargouri, Amina…[et al.]. Bipolar Disorder and Multiple Sclerosis : A Case Series. Behavioural Neurology. 2014. Vol. 2014, no. 2014, pp.1-4.
https://search.emarefa.net/detail/BIM-479534

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references

Record ID

BIM-479534