Cerebrospinal Fluid Biomarkers for Dementia with Lewy Bodies
Joint Authors
Perry, Elaine K.
Mukaetova-Ladinska, Elizabeta B.
Monteith, Rachael
Source
International Journal of Alzheimer's Disease
Issue
Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-17, 17 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-10-17
Country of Publication
Egypt
No. of Pages
17
Main Subjects
Abstract EN
More than 750,000 of the UK population suffer from some form of cognitive impairment and dementia.
Of these, 5–20% will have Dementia with Lewy Bodies (DLB).
Clinico-pathological studies have shown that it is the low frequency of DLB clinical core features that makes the DLB diagnosis hardly recognisable during life, and easily misdiagnosed for other forms of dementia.
This has an impact on the treatment and long-term care of the affected subjects.
Having a biochemical test, based on quantification of a specific DLB biomarker within Cerebrospinal Fluid (CSF) could be an effective diagnostic method to improve the differential diagnosis.
Although some of the investigated DLB CSF biomarkers are well within the clinical criteria for sensitivity and specificity (>90%), they all seem to be confounded by the contradictory data for each of the major groups of biomarkers (α-synuclein, tau and amyloid proteins).
However, a combination of CSF measures appear to emerge, that may well be able to differentiate DLB from other dementias: α-synuclein reduction in early DLB, a correlation between CSF α-synuclein and Aβ42 measures (characteristic for DLB only), and t-tau and p-tau181 profile (differentiating AD from DLB).
American Psychological Association (APA)
Mukaetova-Ladinska, Elizabeta B.& Monteith, Rachael& Perry, Elaine K.. 2010. Cerebrospinal Fluid Biomarkers for Dementia with Lewy Bodies. International Journal of Alzheimer's Disease،Vol. 2010, no. 2010, pp.1-17.
https://search.emarefa.net/detail/BIM-479540
Modern Language Association (MLA)
Mukaetova-Ladinska, Elizabeta B.…[et al.]. Cerebrospinal Fluid Biomarkers for Dementia with Lewy Bodies. International Journal of Alzheimer's Disease No. 2010 (2010), pp.1-17.
https://search.emarefa.net/detail/BIM-479540
American Medical Association (AMA)
Mukaetova-Ladinska, Elizabeta B.& Monteith, Rachael& Perry, Elaine K.. Cerebrospinal Fluid Biomarkers for Dementia with Lewy Bodies. International Journal of Alzheimer's Disease. 2010. Vol. 2010, no. 2010, pp.1-17.
https://search.emarefa.net/detail/BIM-479540
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-479540