Computational Analysis of mRNA Expression Profiles Identifies the ITG Family and PIK3R3 as Crucial Genes for Regulating Triple Negative Breast Cancer Cell Migration
Joint Authors
Wu, Mei-Shin
Klahan, Sukhontip
Chang, Wei Chiao
Hou, Ming-Feng
Huang, Chi-Cheng
Hsi, Edward
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-05-06
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Triple-negative breast cancer (TNBC) is an aggressive type of breast cancer that does not express estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor (Her2/neu).
TNBC has worse clinical outcomes than other breast cancer subtypes.
However, the key molecules and mechanisms of TNBC migration remain unclear.
In this study, we compared two normalized microarray datasets from GEO database between Asian (GSE33926) and non-Asian populations (GSE46581) to determine the molecules and common pathways in TNBC migration.
We demonstrated that 16 genes in non-Asian samples and 9 genes in Asian samples are related to TNBC migration.
In addition, our analytic results showed that 4 genes, PIK3R3, ITGB1, ITGAL, and ITGA6, were involved in the regulation of actin cytoskeleton.
Our results indicated potential genes that link to TNBC migration.
This study may help identify novel therapeutic targets for drug development in cancer therapy.
American Psychological Association (APA)
Klahan, Sukhontip& Wu, Mei-Shin& Hsi, Edward& Huang, Chi-Cheng& Hou, Ming-Feng& Chang, Wei Chiao. 2014. Computational Analysis of mRNA Expression Profiles Identifies the ITG Family and PIK3R3 as Crucial Genes for Regulating Triple Negative Breast Cancer Cell Migration. BioMed Research International،Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-479545
Modern Language Association (MLA)
Klahan, Sukhontip…[et al.]. Computational Analysis of mRNA Expression Profiles Identifies the ITG Family and PIK3R3 as Crucial Genes for Regulating Triple Negative Breast Cancer Cell Migration. BioMed Research International No. 2014 (2014), pp.1-8.
https://search.emarefa.net/detail/BIM-479545
American Medical Association (AMA)
Klahan, Sukhontip& Wu, Mei-Shin& Hsi, Edward& Huang, Chi-Cheng& Hou, Ming-Feng& Chang, Wei Chiao. Computational Analysis of mRNA Expression Profiles Identifies the ITG Family and PIK3R3 as Crucial Genes for Regulating Triple Negative Breast Cancer Cell Migration. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-479545
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-479545