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Stem Cell Therapy in Acute Myocardial Infarction : A Pot of Gold or Pandora's Box
Joint Authors
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-20, 20 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-05-11
Country of Publication
Egypt
No. of Pages
20
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Abstract EN
Stem cell therapy for conditions characterized by myocyte loss in myocardial infarction and heart failure is intuitively appealing.
Stem cells from various sources, including heart itself in preclinical and animal studies, have shown the potential to improve the function of ventricular muscle after ischaemic injury.
The clinical experience from worldwide studies have indicated the safety profile but with modest benefits.
The predominant mechanisms of transplanted cells for improving cardiac function have pointed towards paracrine effects rather than transdifferentiation into cardiomyocytes.
Thus, further investigations should be encouraged towards bench side and bedside to resolve various issues for ensuring the correct type and dosing of cells, time, and method of delivery and identify correct mechanism of functional improvement.
An interdisciplinary effort at the scientific, clinical, and the government front will bring successful realization of this therapy for healing the heart and may convert what seems now a Pandora's Box into a Pot of Gold.
American Psychological Association (APA)
Shah, V. K.& Shalia, K. K.. 2011. Stem Cell Therapy in Acute Myocardial Infarction : A Pot of Gold or Pandora's Box. Stem Cells International،Vol. 2011, no. 2011, pp.1-20.
https://search.emarefa.net/detail/BIM-479555
Modern Language Association (MLA)
Shah, V. K.& Shalia, K. K.. Stem Cell Therapy in Acute Myocardial Infarction : A Pot of Gold or Pandora's Box. Stem Cells International No. 2011 (2011), pp.1-20.
https://search.emarefa.net/detail/BIM-479555
American Medical Association (AMA)
Shah, V. K.& Shalia, K. K.. Stem Cell Therapy in Acute Myocardial Infarction : A Pot of Gold or Pandora's Box. Stem Cells International. 2011. Vol. 2011, no. 2011, pp.1-20.
https://search.emarefa.net/detail/BIM-479555
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-479555