Persistent Sepsis-Induced Hypotension without Hyperlactatemia : A Distinct Clinical and Physiological Profile within the Spectrum of Septic Shock
Joint Authors
Veas, Enrique
Kattan, Eduardo
Fuentealba, Andrea
Pedreros, Cesar
Ruiz, Carolina
Castro, Ricardo
Regueira, Tomas
Bruhn, Alejandro
Rovegno, Maximiliano
Ince, Can
Hernandez, Glenn
Source
Critical Care Research and Practice
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-04-18
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Introduction.
A subgroup of septic shock patients will never develop hyperlactatemia despite being subjected to a massive circulatory stress.
Maintenance of normal lactate levels during septic shock is of great clinical and physiological interest.
Our aim was to describe the clinical, hemodynamic, perfusion, and microcirculatory profiles associated to the absence of hyperlactatemia during septic shock resuscitation.
Methods.
We conducted an observational study in septic shock patients undergoing resuscitation.
Serial clinical, hemodynamic, and perfusion parameters were registered.
A single sublingual microcirculatory assessment was performed in a subgroup.
Patients evolving with versus without hyperlactatemia were compared.
Results.
124 septic shock patients were included.
Patients without hyperlactatemia exhibited lower severity scores and mortality.
They also presented higher platelet counts and required less intensive treatment.
Microcirculation was assessed in 45 patients.
Patients without hyperlactatemia presented higher PPV and MFI values.
Lactate was correlated to several microcirculatory parameters.
No difference in systemic flow parameters was observed.
Conclusion.
Persistent sepsis-induced hypotension without hyperlactatemia is associated with less organ dysfunctions and a very low mortality risk.
Patients without hyperlactatemia exhibit less coagulation and microcirculatory derangements despite comparable macrohemodynamics.
Our study supports the notion that persistent sepsis-induced hypotension without hyperlactatemia exhibits a distinctive clinical and physiological profile.
American Psychological Association (APA)
Hernandez, Glenn& Bruhn, Alejandro& Castro, Ricardo& Pedreros, Cesar& Rovegno, Maximiliano& Kattan, Eduardo…[et al.]. 2012. Persistent Sepsis-Induced Hypotension without Hyperlactatemia : A Distinct Clinical and Physiological Profile within the Spectrum of Septic Shock. Critical Care Research and Practice،Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-479564
Modern Language Association (MLA)
Hernandez, Glenn…[et al.]. Persistent Sepsis-Induced Hypotension without Hyperlactatemia : A Distinct Clinical and Physiological Profile within the Spectrum of Septic Shock. Critical Care Research and Practice No. 2012 (2012), pp.1-7.
https://search.emarefa.net/detail/BIM-479564
American Medical Association (AMA)
Hernandez, Glenn& Bruhn, Alejandro& Castro, Ricardo& Pedreros, Cesar& Rovegno, Maximiliano& Kattan, Eduardo…[et al.]. Persistent Sepsis-Induced Hypotension without Hyperlactatemia : A Distinct Clinical and Physiological Profile within the Spectrum of Septic Shock. Critical Care Research and Practice. 2012. Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-479564
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-479564