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Investigation of Cytotoxicity of Phosphoryl Choline Modified Single-Walled Carbon Nanotubes under a Live Cell Station
Joint Authors
Zhao, Yufeng
Mao, Qunlong
Zhang, Tao
Liu, Yu
Jiang, Zhengsheng
Zhang, Yan
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-06-25
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Single-walled carbon nanotubes (SWCNTs) and various modified SWCNTs have drawn a lot of attention due to their potential applications in biomedical field.
Before further moving on to real clinical applications, hydrophobicity and toxicity of SWCNTs should be investigated thoroughly.
In this paper, 2-methacryloyloxy ethyl phosphorylcholine (MPC) was adopted to modify SWCNTs and phosphoryl choline was grafted onto SWCNTs as small molecule moieties and polymeric chains, which made SWCNTs dispersed stably both in water and in cell culture medium for a long time.
Cytotoxicity of pristine and modified SWCNTs were assayed upon successful preparation of the designed modified SWCNT.
Furthermore, the internalization of SWCNTs by three cells was investigated using a live cell station under normal culture temperature (37°C) and low temperature (4°C).
The results showed that the internalization of modified SWCNTs was related to both the active transport and the passive transport.
Although the modification with phosphoryl choline remarkably reduced the cytotoxicity of SWCNTs, the results were probably due to other reasons such as the decrease in the ratio of cells which internalized modified SWCNTs since the cells without SWCNTs occupation still exhibited normal states.
American Psychological Association (APA)
Zhao, Yufeng& Mao, Qunlong& Liu, Yu& Zhang, Yan& Zhang, Tao& Jiang, Zhengsheng. 2014. Investigation of Cytotoxicity of Phosphoryl Choline Modified Single-Walled Carbon Nanotubes under a Live Cell Station. BioMed Research International،Vol. 2014, no. 2014, pp.1-12.
https://search.emarefa.net/detail/BIM-479580
Modern Language Association (MLA)
Zhao, Yufeng…[et al.]. Investigation of Cytotoxicity of Phosphoryl Choline Modified Single-Walled Carbon Nanotubes under a Live Cell Station. BioMed Research International No. 2014 (2014), pp.1-12.
https://search.emarefa.net/detail/BIM-479580
American Medical Association (AMA)
Zhao, Yufeng& Mao, Qunlong& Liu, Yu& Zhang, Yan& Zhang, Tao& Jiang, Zhengsheng. Investigation of Cytotoxicity of Phosphoryl Choline Modified Single-Walled Carbon Nanotubes under a Live Cell Station. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-12.
https://search.emarefa.net/detail/BIM-479580
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-479580