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Toll-Like Receptors in Hepatic IschemiaReperfusion and Transplantation
Joint Authors
Evankovich, John
Billiar, Timothy R.
Tsung, Allan
Source
Gastroenterology Research and Practice
Issue
Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-08-05
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
The family of Toll-like receptors (TLRs) function as pattern-recognition receptors (PRRs) that respond to a myriad of highly conserved ligands.
These substrates include pathogen-associated molecular patterns (PAMPs) for the recognition of invading pathogens, as well as damage-associated molecular patterns (DAMPs) for the recognition of endogenous tissue injury.
While the functions of TLRs are diverse, they have received much attention for their roles in ischemia/reperfusion (I/R) injury of the liver and other organs.
The TLRs play central roles in sensing tissue damage and activating the innate immune system following I/R.
Engagement of TLRs by endogenous DAMPs activates proinflammatory signaling pathways leading to the production of cytokines, chemokines and further release of endogenous danger signals.
This paper focuses on the most recent findings regarding TLR family members in hepatic I/R injury and transplantation.
American Psychological Association (APA)
Evankovich, John& Billiar, Timothy R.& Tsung, Allan. 2010. Toll-Like Receptors in Hepatic IschemiaReperfusion and Transplantation. Gastroenterology Research and Practice،Vol. 2010, no. 2010, pp.1-8.
https://search.emarefa.net/detail/BIM-479596
Modern Language Association (MLA)
Evankovich, John…[et al.]. Toll-Like Receptors in Hepatic IschemiaReperfusion and Transplantation. Gastroenterology Research and Practice No. 2010 (2010), pp.1-8.
https://search.emarefa.net/detail/BIM-479596
American Medical Association (AMA)
Evankovich, John& Billiar, Timothy R.& Tsung, Allan. Toll-Like Receptors in Hepatic IschemiaReperfusion and Transplantation. Gastroenterology Research and Practice. 2010. Vol. 2010, no. 2010, pp.1-8.
https://search.emarefa.net/detail/BIM-479596
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-479596