Neural Plasticity and Proliferation in the Generation of Antidepressant Effects : Hippocampal Implication
Joint Authors
Martínez-Villayandre, Beatriz
dos Anjos, Severiano
Pascual-Brazo, Jesús
Díaz, Alvaro
Linge, Raquel
Vargas, Veronica
Blanco, Helena
Pazos, Ángel
Valdizán, Elsa M.
Castro, Elena
Pilar-Cuéllar, Fuencisla
Vidal, Rebeca
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-21, 21 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-06-19
Country of Publication
Egypt
No. of Pages
21
Main Subjects
Abstract EN
It is widely accepted that changes underlying depression and antidepressant-like effects involve not only alterations in the levels of neurotransmitters as monoamines and their receptors in the brain, but also structural and functional changes far beyond.
During the last two decades, emerging theories are providing new explanations about the neurobiology of depression and the mechanism of action of antidepressant strategies based on cellular changes at the CNS level.
The neurotrophic/plasticity hypothesis of depression, proposed more than a decade ago, is now supported by multiple basic and clinical studies focused on the role of intracellular-signalling cascades that govern neural proliferation and plasticity.
Herein, we review the state-of-the-art of the changes in these signalling pathways which appear to underlie both depressive disorders and antidepressant actions.
We will especially focus on the hippocampal cellularity and plasticity modulation by serotonin, trophic factors as brain-derived neurotrophic factor (BDNF), and vascular endothelial growth factor (VEGF) through intracellular signalling pathways—cAMP, Wnt/β-catenin, and mTOR.
Connecting the classic monoaminergic hypothesis with proliferation/neuroplasticity-related evidence is an appealing and comprehensive attempt for improving our knowledge about the neurobiological events leading to depression and associated to antidepressant therapies.
American Psychological Association (APA)
Pilar-Cuéllar, Fuencisla& Vidal, Rebeca& Díaz, Alvaro& Castro, Elena& dos Anjos, Severiano& Pascual-Brazo, Jesús…[et al.]. 2013. Neural Plasticity and Proliferation in the Generation of Antidepressant Effects : Hippocampal Implication. Neural Plasticity،Vol. 2013, no. 2013, pp.1-21.
https://search.emarefa.net/detail/BIM-479597
Modern Language Association (MLA)
Pilar-Cuéllar, Fuencisla…[et al.]. Neural Plasticity and Proliferation in the Generation of Antidepressant Effects : Hippocampal Implication. Neural Plasticity No. 2013 (2013), pp.1-21.
https://search.emarefa.net/detail/BIM-479597
American Medical Association (AMA)
Pilar-Cuéllar, Fuencisla& Vidal, Rebeca& Díaz, Alvaro& Castro, Elena& dos Anjos, Severiano& Pascual-Brazo, Jesús…[et al.]. Neural Plasticity and Proliferation in the Generation of Antidepressant Effects : Hippocampal Implication. Neural Plasticity. 2013. Vol. 2013, no. 2013, pp.1-21.
https://search.emarefa.net/detail/BIM-479597
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-479597