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Pulmonary Arterial Hypertension in Adult-Onset Still’s Disease : Rapid Response to Anakinra
Joint Authors
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-08-29
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Adult-onset Still’s disease (AOSD) is a rare inflammatory condition characterized by spiking quotidian fever, rash, chronic arthralgia, leukocytosis, and occasional pulmonary involvement such as pleural effusion and transient pulmonary infiltrates.
Pulmonary arterial hypertension (PAH) is a rare pulmonary complication of AOSD, and we are aware of only 5 cases reported in the literature.
We report the case of a 27-year-old woman of Middle Eastern descent, with a 7-year history of AOSD, who developed severe pulmonary arterial hypertension (PAH).
After unsuccessful exposure to various immunosuppressive regimens, shortly following the initiation of anakinra, an interleukin-1 (IL-1) receptor antagonist, her disease became quiescent and the PAH resolved.
With this case report, we hope to show that anakinra, either by virtue of controlling the overall inflammation in AOSD, or by direct effect on the pulmonary microangiopathy, can improve severe PAH.
American Psychological Association (APA)
Campos, Marc& Schiopu, Elena. 2012. Pulmonary Arterial Hypertension in Adult-Onset Still’s Disease : Rapid Response to Anakinra. Case Reports in Rheumatology،Vol. 2012, no. 2012, pp.1-5.
https://search.emarefa.net/detail/BIM-479635
Modern Language Association (MLA)
Campos, Marc& Schiopu, Elena. Pulmonary Arterial Hypertension in Adult-Onset Still’s Disease : Rapid Response to Anakinra. Case Reports in Rheumatology No. 2012 (2012), pp.1-5.
https://search.emarefa.net/detail/BIM-479635
American Medical Association (AMA)
Campos, Marc& Schiopu, Elena. Pulmonary Arterial Hypertension in Adult-Onset Still’s Disease : Rapid Response to Anakinra. Case Reports in Rheumatology. 2012. Vol. 2012, no. 2012, pp.1-5.
https://search.emarefa.net/detail/BIM-479635
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-479635