Diacylglycerol Signaling Underlies Astrocytic ATP Release
Author
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-08-01
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Astrocytes have the ability to modulate neuronal excitability and synaptic transmission by the release of gliotransmitters.
The importance of ATP released downstream of the activation of Gq-coupled receptors has been well established, but the mechanisms by which this release is regulated are unclear.
The current work reveals that the elevation of diacylglycerol (DAG) in astrocytes induces vesicular ATP release.
Unexpectedly, DAG-induced ATP release was found to be independent of PKC activation, but dependent upon activation of a C1 domain-containing protein.
Astrocytes express the C1 domain-containing protein Munc13-1, which has been implicated in neuronal transmitter release, and RNAi-targeted downregulation of Munc13-1 inhibits astrocytic ATP release.
These studies demonstrate that elevations of DAG induce the exocytotic release of ATP in astrocytes, likely via a Munc13-1-dependent mechanism.
American Psychological Association (APA)
Mungenast, Alison E.. 2011. Diacylglycerol Signaling Underlies Astrocytic ATP Release. Neural Plasticity،Vol. 2011, no. 2011, pp.1-12.
https://search.emarefa.net/detail/BIM-479642
Modern Language Association (MLA)
Mungenast, Alison E.. Diacylglycerol Signaling Underlies Astrocytic ATP Release. Neural Plasticity No. 2011 (2011), pp.1-12.
https://search.emarefa.net/detail/BIM-479642
American Medical Association (AMA)
Mungenast, Alison E.. Diacylglycerol Signaling Underlies Astrocytic ATP Release. Neural Plasticity. 2011. Vol. 2011, no. 2011, pp.1-12.
https://search.emarefa.net/detail/BIM-479642
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-479642