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Advances in Drug Design of Radiometal-Based Imaging Agents for Bone Disorders
Joint Authors
Source
International Journal of Molecular Imaging
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-12-15
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Nuclear medicine bone imaging has been the optimum diagnosis for the detection of bone disorders because the lesion could be detectable before the appearance of symptomatic and radiographic changes.
Over the past three decades, 99mTc-MDP and 99mTc-HMDP have been used as bone scintigraphic agents because of their superior biodistribution characteristics, although they are far from optimal from a chemical and pharmaceutical point of view.
Recently, a more logical drug design has been proposed as a concept of bifunctional radiopharmaceuticals in which the carrier molecules (bisphosphonates) and radiometal chelating groups are separated within a molecule, specifically, 99mTc-mononuclear complex-conjugated bisphosphonate.
Some of the 99mTc-mononuclear complex-conjugated bisphosphonate compounds showed superior biodistribution in preclinical studies.
Moreover, the drug design concept could be applied to 68Ga PET bone imaging agents.
These studies would provide useful information for the development of radiometal-based imaging and therapeutic agents for bone disorders such as bone metastases.
American Psychological Association (APA)
Ogawa, Kazuma& Saji, Hideo. 2011. Advances in Drug Design of Radiometal-Based Imaging Agents for Bone Disorders. International Journal of Molecular Imaging،Vol. 2011, no. 2011, pp.1-7.
https://search.emarefa.net/detail/BIM-479646
Modern Language Association (MLA)
Ogawa, Kazuma& Saji, Hideo. Advances in Drug Design of Radiometal-Based Imaging Agents for Bone Disorders. International Journal of Molecular Imaging No. 2011 (2011), pp.1-7.
https://search.emarefa.net/detail/BIM-479646
American Medical Association (AMA)
Ogawa, Kazuma& Saji, Hideo. Advances in Drug Design of Radiometal-Based Imaging Agents for Bone Disorders. International Journal of Molecular Imaging. 2011. Vol. 2011, no. 2011, pp.1-7.
https://search.emarefa.net/detail/BIM-479646
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-479646