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Protein Kinase C and Toll-Like Receptor Signaling
Joint Authors
Lennartz, Michelle R.
Loegering, Daniel J.
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-08-23
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Protein kinase C (PKC) is a family of kinases that are implicated in a plethora of diseases, including cancer and cardiovascular disease.
PKC isoforms can have different, and sometimes opposing, effects in these disease states.
Toll-like receptors (TLRs) are a family of pattern recognition receptors that bind pathogens and stimulate the secretion of cytokines.
It has long been known that PKC inhibitors reduce LPS-stimulated cytokine secretion by macrophages, linking PKC activation to TLR signaling.
Recent studies have shown that PKC-α, -δ, -ε, and -ζ are directly involved in multiple steps in TLR pathways.
They associate with the TLR or proximal components of the receptor complex.
These isoforms are also involved in the downstream activation of MAPK, RhoA, TAK1, and NF-κB.
Thus, PKC activation is intimately involved in TLR signaling and the innate immune response.
American Psychological Association (APA)
Loegering, Daniel J.& Lennartz, Michelle R.. 2011. Protein Kinase C and Toll-Like Receptor Signaling. Enzyme Research،Vol. 2011, no. 2011, pp.1-7.
https://search.emarefa.net/detail/BIM-479652
Modern Language Association (MLA)
Loegering, Daniel J.& Lennartz, Michelle R.. Protein Kinase C and Toll-Like Receptor Signaling. Enzyme Research No. 2011 (2011), pp.1-7.
https://search.emarefa.net/detail/BIM-479652
American Medical Association (AMA)
Loegering, Daniel J.& Lennartz, Michelle R.. Protein Kinase C and Toll-Like Receptor Signaling. Enzyme Research. 2011. Vol. 2011, no. 2011, pp.1-7.
https://search.emarefa.net/detail/BIM-479652
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-479652