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Glioma Revisited : From Neurogenesis and Cancer Stem Cells to the Epigenetic Regulation of the Niche
Joint Authors
Lunardi Brunetto, Algemir
Abujamra, Ana Lucia
de Almeida Sassi, Felipe
Roesler, Rafael
Schwartsmann, Gilberto
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-20, 20 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-09-02
Country of Publication
Egypt
No. of Pages
20
Main Subjects
Abstract EN
Gliomas are the most incident brain tumor in adults.
This malignancy has very low survival rates, even when combining radio- and chemotherapy.
Among the gliomas, glioblastoma multiforme (GBM) is the most common and aggressive type, and patients frequently relapse or become refractory to conventional therapies.
The fact that such an aggressive tumor can arise in such a carefully orchestrated organ, where cellular proliferation is barely needed to maintain its function, is a question that has intrigued scientists until very recently, when the discovery of the existence of proliferative cells in the brain overcame such challenges.
Even so, the precise origin of gliomas still remains elusive.
Thanks to new advents in molecular biology, researchers have been able to depict the first steps of glioma formation and to accumulate knowledge about how neural stem cells and its progenitors become gliomas.
Indeed, GBM are composed of a very heterogeneous population of cells, which exhibit a plethora of tumorigenic properties, supporting the presence of cancer stem cells (CSCs) in these tumors.
This paper provides a comprehensive analysis of how gliomas initiate and progress, taking into account the role of epigenetic modulation in the crosstalk of cancer cells with their environment.
American Psychological Association (APA)
de Almeida Sassi, Felipe& Lunardi Brunetto, Algemir& Schwartsmann, Gilberto& Roesler, Rafael& Abujamra, Ana Lucia. 2012. Glioma Revisited : From Neurogenesis and Cancer Stem Cells to the Epigenetic Regulation of the Niche. Journal of Oncology،Vol. 2012, no. 2012, pp.1-20.
https://search.emarefa.net/detail/BIM-479655
Modern Language Association (MLA)
de Almeida Sassi, Felipe…[et al.]. Glioma Revisited : From Neurogenesis and Cancer Stem Cells to the Epigenetic Regulation of the Niche. Journal of Oncology No. 2012 (2012), pp.1-20.
https://search.emarefa.net/detail/BIM-479655
American Medical Association (AMA)
de Almeida Sassi, Felipe& Lunardi Brunetto, Algemir& Schwartsmann, Gilberto& Roesler, Rafael& Abujamra, Ana Lucia. Glioma Revisited : From Neurogenesis and Cancer Stem Cells to the Epigenetic Regulation of the Niche. Journal of Oncology. 2012. Vol. 2012, no. 2012, pp.1-20.
https://search.emarefa.net/detail/BIM-479655
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-479655