Effect of Modulated Alternating and Direct Current Iontophoresis on Transdermal Delivery of Lidocaine Hydrochloride
Joint Authors
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-05-15
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
The objective of this study was to investigate the iontophoretic delivery of lidocaine hydrochloride through porcine skin and to compare the effects of modulated alternating and direct current iontophoresis.
Continuous and modulated iontophoresis was applied for one hour and two hours (0-1 h and 4-5th h) using a 1% w/v solution of lidocaine hydrochloride.
Tape stripping was done to quantify the amount of drug permeated into stratum corneum and skin extraction studies were performed to determine the amount of drug in stripped skin.
Receptor was sampled and analyzed over predefined time periods.
The amount of lidocaine delivered across porcine skin after modulated direct current iontophoresis for 2 h was 1069.87±120.03 μg/sq·cm compared to 744.81±125.41 μg/sq·cm after modulated alternating current iontophoresis for 2 h.
Modulated direct current iontophoresis also enhanced lidocaine delivery by twelvefold compared to passive delivery as 91.27±18.71 μg/sq·cm of lidocaine was delivered after passive delivery.
Modulated iontophoresis enhanced the delivery of lidocaine hydrochloride across porcine skin compared to the passive delivery.
Modulated alternating current iontophoresis for duration of 2 h at frequency of 1 kHz was found to be comparable to the continuous direct current iontophoresis for 1 h.
American Psychological Association (APA)
Bhatia, Gaurav& Banga, Ajay K.. 2014. Effect of Modulated Alternating and Direct Current Iontophoresis on Transdermal Delivery of Lidocaine Hydrochloride. BioMed Research International،Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-479662
Modern Language Association (MLA)
Bhatia, Gaurav& Banga, Ajay K.. Effect of Modulated Alternating and Direct Current Iontophoresis on Transdermal Delivery of Lidocaine Hydrochloride. BioMed Research International No. 2014 (2014), pp.1-6.
https://search.emarefa.net/detail/BIM-479662
American Medical Association (AMA)
Bhatia, Gaurav& Banga, Ajay K.. Effect of Modulated Alternating and Direct Current Iontophoresis on Transdermal Delivery of Lidocaine Hydrochloride. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-479662
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-479662