The Gene-Gene Interaction of INSIG-SCAP-SREBP Pathway on the Risk of Obesity in Chinese Children
Joint Authors
Wang, Hai-Jun
Liu, Fang-Hong
Ma, Jun
Shang, Xiao-Rui
Meng, Xiang-Rui
Song, Jie-Yun
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-06-17
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Background.
Childhood obesity has become a global public health problem in recent years.
This study aimed to explore the association of genetic variants in INSIG-SCAP-SREBP pathway with obesity in Chinese children.
Methods.
A case-control study was conducted, including 705 obese cases and 1,325 nonobese controls.
We genotyped 15 single nucleotide polymorphisms (SNPs) of five genes in INSIG-SCAP-SREBP pathway, including insulin induced gene 1 (INSIG1), insulin induced gene 2 (INSIG2), SREBP cleavage-activating protein gene (SCAP), sterol regulatory element binding protein gene 1 (SREBP1), and sterol regulatory element binding protein gene 2 (SREBP2).
We used generalized multifactor dimensionality reduction (GMDR) and logistic regression to investigate gene-gene interactions.
Results.
Single polymorphism analyses showed that SCAP rs12487736 and rs12490383 were nominally associated with obesity.
We identified a 3-locus interaction on obesity in GMDR analyses (P=0.001), involving 3 genetic variants of INSIG2, SCAP, and SREBP2.
The individuals in high-risk group of the 3-locus combinations had a 79.9% increased risk of obesity compared with those in low-risk group (OR=1.799, 95% CI: 1.475–2.193, P=6.61×10-9).
Conclusion.
We identified interaction of three genes in INSIG-SCAP-SREBP pathway on risk of obesity, revealing that these genes affect obesity more likely through a complex interaction pattern than single gene effect.
American Psychological Association (APA)
Liu, Fang-Hong& Song, Jie-Yun& Shang, Xiao-Rui& Meng, Xiang-Rui& Ma, Jun& Wang, Hai-Jun. 2014. The Gene-Gene Interaction of INSIG-SCAP-SREBP Pathway on the Risk of Obesity in Chinese Children. BioMed Research International،Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-479717
Modern Language Association (MLA)
Liu, Fang-Hong…[et al.]. The Gene-Gene Interaction of INSIG-SCAP-SREBP Pathway on the Risk of Obesity in Chinese Children. BioMed Research International No. 2014 (2014), pp.1-8.
https://search.emarefa.net/detail/BIM-479717
American Medical Association (AMA)
Liu, Fang-Hong& Song, Jie-Yun& Shang, Xiao-Rui& Meng, Xiang-Rui& Ma, Jun& Wang, Hai-Jun. The Gene-Gene Interaction of INSIG-SCAP-SREBP Pathway on the Risk of Obesity in Chinese Children. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-479717
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-479717