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Renal Manifestations in Scleroderma : Evidence for Subclinical Renal Disease as a Marker of Vasculopathy
Joint Authors
Steen, Virginia D.
Shanmugam, Victoria K.
Source
International Journal of Rheumatology
Issue
Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-08-17
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Scleroderma is a disease characterized by immune activation, vasculopathy, fibroblast stimulation, and connective tissue fibrosis.
End-organ damage occurs due to progressive tissue fibrosis and vasculopathy.
Markers of incipient vasculopathy have not been well studied in scleroderma.
However, reduced renal functional reserve and proteinuria are common indicators of progressive vasculopathy in diabetic and hypertensive vasculopathy.
Recent studies suggest a strong association between renal involvement and outcomes in scleroderma, with a threefold increased risk of mortality from pulmonary hypertension if renal insufficiency is present.
We review the types of renal involvement seen in scleroderma and the data to support the use of renal parameters including proteinuria, glomerular filtration rate, and renal vascular dynamics measured with Doppler ultrasound to identify subclinical renal insufficiency.
Further studies are warranted to investigate the use of renal parameters as prognostic indicators in scleroderma.
American Psychological Association (APA)
Shanmugam, Victoria K.& Steen, Virginia D.. 2010. Renal Manifestations in Scleroderma : Evidence for Subclinical Renal Disease as a Marker of Vasculopathy. International Journal of Rheumatology،Vol. 2010, no. 2010, pp.1-8.
https://search.emarefa.net/detail/BIM-479720
Modern Language Association (MLA)
Shanmugam, Victoria K.& Steen, Virginia D.. Renal Manifestations in Scleroderma : Evidence for Subclinical Renal Disease as a Marker of Vasculopathy. International Journal of Rheumatology No. 2010 (2010), pp.1-8.
https://search.emarefa.net/detail/BIM-479720
American Medical Association (AMA)
Shanmugam, Victoria K.& Steen, Virginia D.. Renal Manifestations in Scleroderma : Evidence for Subclinical Renal Disease as a Marker of Vasculopathy. International Journal of Rheumatology. 2010. Vol. 2010, no. 2010, pp.1-8.
https://search.emarefa.net/detail/BIM-479720
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-479720