Human Antibodies Can Cross Guinea Pig Placenta and Bind Its Neonatal Fc Receptor : Implications for Studying Immune Prophylaxis and Therapy during Pregnancy
Joint Authors
Ma, Li
Beren, Joel
Zhong, Lilin
Struble, Evi Budo
Zhang, Pei
Lesher, A.
Source
Clinical and Developmental Immunology
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-09-09
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Despite increased use of monoclonal and polyclonal antibody therapies, including during pregnancy, there is little data on appropriate animal models that could humanely be used to understand determinants of protection and to evaluate safety of these biologics in the mother and the developing fetus.
Here, we demonstrate that pregnant guinea pigs can transport human IgG transplacentally at the end of pregnancy.
We also observe that human IgG binds to an engineered soluble variant of the guinea pig neonatal Fc receptor in vitro in a manner similar to that demonstrated for the human variant, suggesting that this transplacental transport mirrors the receptor-based mechanism seen in humans.
Using an intravenous antihepatitis B-specific immune globulin preparation as an example, we show that this transport results in neutralizing activity in the mother and the newborn that would potentially be prophylactic against hepatitis B viral infection.
These preliminary data lay the groundwork for introducing pregnant guinea pigs as an appropriate model for the evaluation of antibody therapies and advancing the health of women and neonates.
American Psychological Association (APA)
Struble, Evi Budo& Ma, Li& Zhong, Lilin& Lesher, A.& Beren, Joel& Zhang, Pei. 2012. Human Antibodies Can Cross Guinea Pig Placenta and Bind Its Neonatal Fc Receptor : Implications for Studying Immune Prophylaxis and Therapy during Pregnancy. Clinical and Developmental Immunology،Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-479736
Modern Language Association (MLA)
Struble, Evi Budo…[et al.]. Human Antibodies Can Cross Guinea Pig Placenta and Bind Its Neonatal Fc Receptor : Implications for Studying Immune Prophylaxis and Therapy during Pregnancy. Clinical and Developmental Immunology No. 2012 (2012), pp.1-9.
https://search.emarefa.net/detail/BIM-479736
American Medical Association (AMA)
Struble, Evi Budo& Ma, Li& Zhong, Lilin& Lesher, A.& Beren, Joel& Zhang, Pei. Human Antibodies Can Cross Guinea Pig Placenta and Bind Its Neonatal Fc Receptor : Implications for Studying Immune Prophylaxis and Therapy during Pregnancy. Clinical and Developmental Immunology. 2012. Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-479736
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-479736