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Combined Lung Transfer of NO and CO in Patients Receiving Methotrexate or Bleomycin Therapy Compared to Normal Subjects
Joint Authors
Gormand, Frédéric
Couraud, Sébastien
Pacheco, Yves
Viart-Ferber, Chantal
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-01-29
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
The first aim of the study is to determine whether combined lung diffusing capacities of nitric oxide (TLNO) and of carbon monoxide (TLCO) are accurate in the followup of patients receiving either methotrexate (MTX) or bleomycin (BLM).
The second objective is to determine whether TLCO, TLNO, KCO, and TLCO/VI% (inspiratory volume expressed as percentage of predicted value) correlate better with the diffusing capacity of the membrane (Dm) and/or capillary lung volume (Vc).
TLNO and TLCO were measured in three groups: 22 “normal” subjects (N group), 17 patients receiving MTX, and 12 patients treated with BLM.
TLCO, TLNO, Dm, and Vc were much lower in the MTX and BLM groups compared to those of the N one.
The ratio TLNO/TLCO was higher in the BLM group compared to that of the N group and compared to that of the MTX group.
KCO correlated neither with Dc nor with Vc, whereas TLCO/VI% correlated significantly with both Dm and Vc.
Combined measurement of TLCO and TLNO seems to be useful in the followup of patients receiving agents inducing lung toxicity and gives a good idea of the alveolar membrane and the capillary volume.
American Psychological Association (APA)
Viart-Ferber, Chantal& Couraud, Sébastien& Gormand, Frédéric& Pacheco, Yves. 2013. Combined Lung Transfer of NO and CO in Patients Receiving Methotrexate or Bleomycin Therapy Compared to Normal Subjects. Physiology Journal،Vol. 2013, no. 2013, pp.1-6.
https://search.emarefa.net/detail/BIM-479757
Modern Language Association (MLA)
Viart-Ferber, Chantal…[et al.]. Combined Lung Transfer of NO and CO in Patients Receiving Methotrexate or Bleomycin Therapy Compared to Normal Subjects. Physiology Journal No. 2013 (2013), pp.1-6.
https://search.emarefa.net/detail/BIM-479757
American Medical Association (AMA)
Viart-Ferber, Chantal& Couraud, Sébastien& Gormand, Frédéric& Pacheco, Yves. Combined Lung Transfer of NO and CO in Patients Receiving Methotrexate or Bleomycin Therapy Compared to Normal Subjects. Physiology Journal. 2013. Vol. 2013, no. 2013, pp.1-6.
https://search.emarefa.net/detail/BIM-479757
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-479757