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Evaluation of a Set of C9 N-acyl Neu5Ac2en Mimetics as Viral Sialidase Selective Inhibitors
Joint Authors
Ishida, Hideharu
Moriya, Setsuko
Suzuki, Yasuo
Ando, Hiromune
Miyagi, Taeko
Kiso, Makoto
Magesh, Sadagopan
Sriwilaijaroen, Nongluk
Source
International Journal of Medicinal Chemistry
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-12-28
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Identification of selective influenza viral sialidase inhibitors is highly desirable in order to minimize or avoid the adverse effects due to the possible inhibition of endogenous human sialidases.
We recently reported the evaluation of C9 N-acyl Neu5Ac2en mimetics as probes for human sialidases.
Herein, we describe the in vitro activity of the same set of C9 N-acyl Neu5Ac2en mimetics against sialidases expressed by influenza virus A/PR/8/34 (H1N1), A/Memphis/1/72 (H3N2), and A/Duck/313/78 (H5N3) strains.
Compound 8 is identified as a promising starting point for the development of viral sialidase selective inhibitors.
Multiple sequence alignment and molecular docking techniques are also performed to explore the plausible interaction of compound 8 with viral sialidases.
American Psychological Association (APA)
Magesh, Sadagopan& Sriwilaijaroen, Nongluk& Moriya, Setsuko& Ando, Hiromune& Miyagi, Taeko& Suzuki, Yasuo…[et al.]. 2010. Evaluation of a Set of C9 N-acyl Neu5Ac2en Mimetics as Viral Sialidase Selective Inhibitors. International Journal of Medicinal Chemistry،Vol. 2011, no. 2011, pp.1-7.
https://search.emarefa.net/detail/BIM-479778
Modern Language Association (MLA)
Magesh, Sadagopan…[et al.]. Evaluation of a Set of C9 N-acyl Neu5Ac2en Mimetics as Viral Sialidase Selective Inhibitors. International Journal of Medicinal Chemistry No. 2011 (2011), pp.1-7.
https://search.emarefa.net/detail/BIM-479778
American Medical Association (AMA)
Magesh, Sadagopan& Sriwilaijaroen, Nongluk& Moriya, Setsuko& Ando, Hiromune& Miyagi, Taeko& Suzuki, Yasuo…[et al.]. Evaluation of a Set of C9 N-acyl Neu5Ac2en Mimetics as Viral Sialidase Selective Inhibitors. International Journal of Medicinal Chemistry. 2010. Vol. 2011, no. 2011, pp.1-7.
https://search.emarefa.net/detail/BIM-479778
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-479778