Quantitative Estimation of Sorafenib Tosylate Its Pure Form and in Its Tablet Formulation by RP-HPLC Method
Joint Authors
Kalaichelvi, R.
Jayachandran, E.
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-3, 3 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-08-16
Country of Publication
Egypt
No. of Pages
3
Main Subjects
Abstract EN
A simple, accurate, specific reverse-phase, high-performance liquid chromatography method has been developed for the determination of sorafenib tosylate in its pure form and its tablets.
In this method, sorafenib tosylate was eluted by isocratic mode using a Phenomenex Luna C18 column by a mobile phase composition of acetonitrile and water in the ratio of 82.5 : 17.5, v/v.
The flow rate was 1.5 mL/min.
The eluted drug was monitored at 265 nm and the method was found to be linear from 5 to 80 μg/mL.
The method was validated by linearity, precision, accuracy, LOD, and LOQ.
The accuracy report denotes that there is not any interference of additives used in the formulation.
American Psychological Association (APA)
Kalaichelvi, R.& Jayachandran, E.. 2012. Quantitative Estimation of Sorafenib Tosylate Its Pure Form and in Its Tablet Formulation by RP-HPLC Method. Journal of Chemistry،Vol. 2013, no. 2013, pp.1-3.
https://search.emarefa.net/detail/BIM-479782
Modern Language Association (MLA)
Kalaichelvi, R.& Jayachandran, E.. Quantitative Estimation of Sorafenib Tosylate Its Pure Form and in Its Tablet Formulation by RP-HPLC Method. Journal of Chemistry No. 2013 (2013), pp.1-3.
https://search.emarefa.net/detail/BIM-479782
American Medical Association (AMA)
Kalaichelvi, R.& Jayachandran, E.. Quantitative Estimation of Sorafenib Tosylate Its Pure Form and in Its Tablet Formulation by RP-HPLC Method. Journal of Chemistry. 2012. Vol. 2013, no. 2013, pp.1-3.
https://search.emarefa.net/detail/BIM-479782
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-479782
