Expressions of MMPs and TIMP-1 in Gastric Ulcers May Differentiate H. pylori-Infected from NSAID-Related Ulcers
Joint Authors
Sheu, Bor-Shyang
Chen, Wei-Ying
Chang, Wei-Lun
Cheng, Hsiu-Chi
Yeh, Yi-Chun
Yang, Hsiao-Bai
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-05-01
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Medicine
Information Technology and Computer Science
Abstract EN
Background.
Two major causes of gastric ulcers are Helicobacter pylori (H.
pylori) infection and nonsteroidal anti-inflammatory drug (NSAID) use.
Aims.
This study aimed to determine if there were different expressions of matrix metalloproteinases (MMPs) and tissue inhibitor of matrix metalloproteinase-1 (TIMP-1) between H.
pylori-infected and NSAID-related ulcers.
Methods.
The 126 gastric ulcer patients (H.
pylori infected n=46; NSAID related n=30; combined with two factors n=50) provided ulcer and nonulcer tissues for assessment of MMP-3, -7, and -9 and TIMP-1 expression by immunohistochemical staining.
Results.
Gastric ulcer tissues had significantly higher MMP-3, -7, and -9 and TIMP-1 expressions than nonulcer tissues (P<0.05).
H.
pylori-infected gastric ulcers had even higher MMP-7, MMP-9, and TIMP-1 expressions in epithelial cells than NSAID-related gastric ulcers (P<0.05).
In patients with the two combined factors, gastric ulcers expressed similar proportions of antral ulcers and MMP-7 and MMP-9 intensities to NSAID-related gastric ulcers, but lower MMP-9 and TIMP-1 than H.
pylori-infected gastric ulcers (P<0.05).
Conclusions.
H.
pylori-infected gastric ulcers express higher MMP-7, MMP-9, and TIMP-1 than NSAID-related ulcers.
In patients with the two combined factors, ulcer location and MMP-7 and MMP-9 intensities are similar to NSAID use.
American Psychological Association (APA)
Cheng, Hsiu-Chi& Yang, Hsiao-Bai& Chang, Wei-Lun& Chen, Wei-Ying& Yeh, Yi-Chun& Sheu, Bor-Shyang. 2012. Expressions of MMPs and TIMP-1 in Gastric Ulcers May Differentiate H. pylori-Infected from NSAID-Related Ulcers. The Scientific World Journal،Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-479790
Modern Language Association (MLA)
Cheng, Hsiu-Chi…[et al.]. Expressions of MMPs and TIMP-1 in Gastric Ulcers May Differentiate H. pylori-Infected from NSAID-Related Ulcers. The Scientific World Journal No. 2012 (2012), pp.1-9.
https://search.emarefa.net/detail/BIM-479790
American Medical Association (AMA)
Cheng, Hsiu-Chi& Yang, Hsiao-Bai& Chang, Wei-Lun& Chen, Wei-Ying& Yeh, Yi-Chun& Sheu, Bor-Shyang. Expressions of MMPs and TIMP-1 in Gastric Ulcers May Differentiate H. pylori-Infected from NSAID-Related Ulcers. The Scientific World Journal. 2012. Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-479790
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-479790