Health Implications of High Dietary Omega-6 Polyunsaturated Fatty Acids
Joint Authors
Ross, R. Paul
Wall, Rebecca
Fitzgerald, Gerald
Stanton, Catherine
Patterson, E.
Source
Journal of Nutrition and Metabolism
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-16, 16 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-04-05
Country of Publication
Egypt
No. of Pages
16
Main Subjects
Abstract EN
Omega-6 (n-6) polyunsaturated fatty acids (PUFA) (e.g., arachidonic acid (AA)) and omega-3 (n-3) PUFA (e.g., eicosapentaenoic acid (EPA)) are precursors to potent lipid mediator signalling molecules, termed “eicosanoids,” which have important roles in the regulation of inflammation.
In general, eicosanoids derived from n-6 PUFA are proinflammatory while eicosanoids derived from n-3 PUFA are anti-inflammatory.
Dietary changes over the past few decades in the intake of n-6 and n-3 PUFA show striking increases in the (n-6) to (n-3) ratio (~15 : 1), which are associated with greater metabolism of the n-6 PUFA compared with n-3 PUFA.
Coinciding with this increase in the ratio of (n-6) : (n-3) PUFA are increases in chronic inflammatory diseases such as nonalcoholic fatty liver disease (NAFLD), cardiovascular disease, obesity, inflammatory bowel disease (IBD), rheumatoid arthritis, and Alzheimer's disease (AD).
By increasing the ratio of (n-3) : (n-6) PUFA in the Western diet, reductions may be achieved in the incidence of these chronic inflammatory diseases.
American Psychological Association (APA)
Patterson, E.& Wall, Rebecca& Fitzgerald, Gerald& Ross, R. Paul& Stanton, Catherine. 2012. Health Implications of High Dietary Omega-6 Polyunsaturated Fatty Acids. Journal of Nutrition and Metabolism،Vol. 2012, no. 2012, pp.1-16.
https://search.emarefa.net/detail/BIM-479805
Modern Language Association (MLA)
Patterson, E.…[et al.]. Health Implications of High Dietary Omega-6 Polyunsaturated Fatty Acids. Journal of Nutrition and Metabolism No. 2012 (2012), pp.1-16.
https://search.emarefa.net/detail/BIM-479805
American Medical Association (AMA)
Patterson, E.& Wall, Rebecca& Fitzgerald, Gerald& Ross, R. Paul& Stanton, Catherine. Health Implications of High Dietary Omega-6 Polyunsaturated Fatty Acids. Journal of Nutrition and Metabolism. 2012. Vol. 2012, no. 2012, pp.1-16.
https://search.emarefa.net/detail/BIM-479805
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-479805