The Th17IL-23 Axis and Natural Immunity in Psoriatic Arthritis
Joint Authors
Maeda, Shinji
Hayami, Yoshihito
Ueda, Ryuzo
Naniwa, Taio
Source
International Journal of Rheumatology
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-04-01
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Psoriatic arthritis (PsA) is a chronic inflammatory skin disease that causes enthesitis and destructive arthritis and significantly lowers patient quality of life.
Recognition of the two target organs (the skin and joints) involved in the immunopathophysiology of PsA helped in elucidating the pathology of various systemic autoimmune diseases targeting multiple organs.
Recent advances in immunology and genetics have made it clear that acquired immunity, especially that mediated by the Th17/IL-23 axis, plays an important role in the inflammatory pathology observed in psoriasis and PsA.
Additionally, involvement of natural immunity has also been suggested.
Microbial infection has been known to trigger psoriasis and PsA.
Recent clinical studies using biopharmaceuticals, such as tumor-necrosis-factor- (TNF-) α inhibitors and IL-12/23 p40 antibodies, indicate that studies need not be based only on the immunological phenomena observed in PsA pathology since disease pathology can now be verified using human-based science.
Considering this aspect, this paper discusses the immunopathology of PsA compared to psoriasis (cutaneous) and rheumatoid arthritis in humans and immunopathology of PsA with respect to the Th17/IL-23 axis and microbial infection.
American Psychological Association (APA)
Maeda, Shinji& Hayami, Yoshihito& Naniwa, Taio& Ueda, Ryuzo. 2012. The Th17IL-23 Axis and Natural Immunity in Psoriatic Arthritis. International Journal of Rheumatology،Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-479833
Modern Language Association (MLA)
Maeda, Shinji…[et al.]. The Th17IL-23 Axis and Natural Immunity in Psoriatic Arthritis. International Journal of Rheumatology No. 2012 (2012), pp.1-8.
https://search.emarefa.net/detail/BIM-479833
American Medical Association (AMA)
Maeda, Shinji& Hayami, Yoshihito& Naniwa, Taio& Ueda, Ryuzo. The Th17IL-23 Axis and Natural Immunity in Psoriatic Arthritis. International Journal of Rheumatology. 2012. Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-479833
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-479833