Comparative Study of Human Hematopoietic Cell Engraftment into Balbc and C57BL6 Strain of Rag-2Jak3 Double-Deficient Mice
Joint Authors
Okada, Seiji
Suzu, Shinya
Kariya, Ryusho
Harada, Hideki
Ono, Ayumi
Taura, Manabu
Iwanaga, Sumako
Hattori, Shinichiro
Source
Journal of Biomedicine and Biotechnology
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-01-26
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Immunodeficient mice are becoming invaluable tools in human stem cell and tumor research.
In this study, we generated Rag-2/Jak3 double-deficient (Rag-2−/−Jak3−/−) mice with a C57/BL6 and Balb/c genetic background and compared the human lymphohematopoietic cell engraftment rate.
Human cord blood-derived CD34+ hematopoietic stem cells were successfully engrafted into Balb/c Rag-2−/−Jak3−/− mice; however, the engraftment rate was far lower in C57/BL6 Rag-2−/−Jak3−/− mice.
Transplantation of human peripheral blood mononuclear cells resulted in the same tendency.
Thus, a Balb/c background offers superior engraftment capacity than a C57/BL6 background and provides an attractive model for human hematopoietic cell engraftment.
American Psychological Association (APA)
Ono, Ayumi& Hattori, Shinichiro& Kariya, Ryusho& Iwanaga, Sumako& Taura, Manabu& Harada, Hideki…[et al.]. 2011. Comparative Study of Human Hematopoietic Cell Engraftment into Balbc and C57BL6 Strain of Rag-2Jak3 Double-Deficient Mice. Journal of Biomedicine and Biotechnology،Vol. 2011, no. 2011, pp.1-6.
https://search.emarefa.net/detail/BIM-479844
Modern Language Association (MLA)
Ono, Ayumi…[et al.]. Comparative Study of Human Hematopoietic Cell Engraftment into Balbc and C57BL6 Strain of Rag-2Jak3 Double-Deficient Mice. Journal of Biomedicine and Biotechnology No. 2011 (2011), pp.1-6.
https://search.emarefa.net/detail/BIM-479844
American Medical Association (AMA)
Ono, Ayumi& Hattori, Shinichiro& Kariya, Ryusho& Iwanaga, Sumako& Taura, Manabu& Harada, Hideki…[et al.]. Comparative Study of Human Hematopoietic Cell Engraftment into Balbc and C57BL6 Strain of Rag-2Jak3 Double-Deficient Mice. Journal of Biomedicine and Biotechnology. 2011. Vol. 2011, no. 2011, pp.1-6.
https://search.emarefa.net/detail/BIM-479844
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-479844