The Presence of Anti-HLA Antibodies before and after Allogeneic Hematopoietic Stem Cells Transplantation from HLA-Mismatched Unrelated Donors

Joint Authors

Markiewicz, Miroslaw
Kyrcz-Krzemien, Slawomira
Dzierzak-Mietla, Monika
Koclega, Anna
Dobrowolska, Alicja
Zielinska, Patrycja
Sobczyk Kruszelnicka, Malgorzata
Lange, Andrzej
Sylwia, Mizia
Siekiera, Urszula

Source

Bone Marrow Research

Issue

Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-7, 7 p.

Publisher

Hindawi Publishing Corporation

Publication Date

2012-10-24

Country of Publication

Egypt

No. of Pages

7

Main Subjects

Biology

Abstract EN

Although anti-human leukocyte antigen antibodies (anti-HLA Abs) are important factors responsible for graft rejection in solid organ transplantation and play a role in post-transfusion complications, their role in allogeneic hematopoietic stem cell transplantation (allo-HSCT) has not been finally defined.

Enormous polymorphism of HLA-genes, their immunogenicity and heterogeneity of antibodies, as well as the growing number of allo-HSCTs from partially HLA-mismatched donors, increase the probability that anti-HLA antibodies could be important factors responsible for the treatment outcomes.

We have examined the incidence of anti-HLA antibodies in a group of 30 allo-HSCT recipients from HLA-mismatched unrelated donors.

Anti-HLA Abs were identified in sera collected before and after allo-HSCT.

We have used automated DynaChip assay utilizing microchips bearing purified class I and II HLA antigens for detection of anti-HLA Abs.

We have detected anit-HLA antibodies against HLA-A, B, C, DR, DQ and DP, but no donor or recipient-specific anti-HLA Abs were detected in the studied group.

The preliminary results indicate that anti-HLA antibodies are present before and after allo-HSCT in HLA-mismatched recipients.

American Psychological Association (APA)

Koclega, Anna& Markiewicz, Miroslaw& Siekiera, Urszula& Dobrowolska, Alicja& Sylwia, Mizia& Dzierzak-Mietla, Monika…[et al.]. 2012. The Presence of Anti-HLA Antibodies before and after Allogeneic Hematopoietic Stem Cells Transplantation from HLA-Mismatched Unrelated Donors. Bone Marrow Research،Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-479855

Modern Language Association (MLA)

Koclega, Anna…[et al.]. The Presence of Anti-HLA Antibodies before and after Allogeneic Hematopoietic Stem Cells Transplantation from HLA-Mismatched Unrelated Donors. Bone Marrow Research No. 2012 (2012), pp.1-7.
https://search.emarefa.net/detail/BIM-479855

American Medical Association (AMA)

Koclega, Anna& Markiewicz, Miroslaw& Siekiera, Urszula& Dobrowolska, Alicja& Sylwia, Mizia& Dzierzak-Mietla, Monika…[et al.]. The Presence of Anti-HLA Antibodies before and after Allogeneic Hematopoietic Stem Cells Transplantation from HLA-Mismatched Unrelated Donors. Bone Marrow Research. 2012. Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-479855

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references

Record ID

BIM-479855