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Dendritic Cells in Cord Blood Transplantation : A Review
Joint Authors
Pereira, Marta Isabel
Paiva, Artur
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-06-16
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Abstract EN
Dendritic cells (DCs) are a heterogeneous population of antigen-presenting cells derived from hematopoietic progenitors that bridge the transition between the innate and adaptive immune responses, while maintaining self-tolerance and Th1/Th2 homeostasis, by priming other cells in either an immunogenic or tolerogenic direction.
Through their role in both innate and adaptive immunity, DCs play a major part in transplant engraftment and rejection and in graft-versus-host disease (GvHD).
Preferentially tolerogenic or immunogenic DC subtypes offer targets for immunotherapy, to optimize transplant success rates and prolong disease-free and overall survival.
Cord blood DCs are immature and preferentially tolerogenic, due to maternal-fetal tolerance, leading to better graft acceptance and immune reconstitution and explaining the lower incidence and severity of GvHD in CB transplantation, despite donor-host mismatching.
Manipulation of DC maturation and cell loading with tumor-antigens can direct antitumor immunity and target minimal residual disease, as demonstrated for acute myeloid leukemia, optimizing the graft-versus-leukemia effect.
American Psychological Association (APA)
Pereira, Marta Isabel& Paiva, Artur. 2011. Dendritic Cells in Cord Blood Transplantation : A Review. Stem Cells International،Vol. 2011, no. 2011, pp.1-7.
https://search.emarefa.net/detail/BIM-479861
Modern Language Association (MLA)
Pereira, Marta Isabel& Paiva, Artur. Dendritic Cells in Cord Blood Transplantation : A Review. Stem Cells International No. 2011 (2011), pp.1-7.
https://search.emarefa.net/detail/BIM-479861
American Medical Association (AMA)
Pereira, Marta Isabel& Paiva, Artur. Dendritic Cells in Cord Blood Transplantation : A Review. Stem Cells International. 2011. Vol. 2011, no. 2011, pp.1-7.
https://search.emarefa.net/detail/BIM-479861
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-479861