Chemoprevention of Head and Neck Cancer by Green Tea Extract : EGCG—The Role of EGFR Signaling and “Lipid Raft”
Joint Authors
Adachi, Seiji
Wakasaki, Takahiro
Toh, Satoshi
Shimizu, Masahito
Masuda, Muneyuki
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-01-02
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Over the past decade dose-intensified chemo-radiotherapy or molecular targeted therapy has been introduced into the treatments of head and neck squamous cell carcinoma (HNSCC) to improve the outcomes of this dismal disease.
However, these strategies have revealed only limited efficacy so far.
Moreover, the frequent occurrences of second primary tumor further worsen the prognosis of patients.
In this context, early detection and chemoprevention appear to be a realistic and effective method to improve the prognosis as well as quality of life in patients with HNSCC.
In this short paper, we discuss the potential of green tea extract, (-)-epigallocatechin-3-galate (EGCG) in HNSCC chemoprevention, focusing on two aspects that are provided recently: (1) evidence of clinical efficacy and (2) unique biological effects on “lipid raft” that emerged as an important platform of numerous biophysical functions, for example, receptor tyrosin kinases (RTKs) signalings including epidermal growth factor receptor (EGFR), which play critical roles in HNSCC carcinogenesis.
American Psychological Association (APA)
Masuda, Muneyuki& Wakasaki, Takahiro& Toh, Satoshi& Shimizu, Masahito& Adachi, Seiji. 2011. Chemoprevention of Head and Neck Cancer by Green Tea Extract : EGCG—The Role of EGFR Signaling and “Lipid Raft”. Journal of Oncology،Vol. 2011, no. 2011, pp.1-7.
https://search.emarefa.net/detail/BIM-479866
Modern Language Association (MLA)
Masuda, Muneyuki…[et al.]. Chemoprevention of Head and Neck Cancer by Green Tea Extract : EGCG—The Role of EGFR Signaling and “Lipid Raft”. Journal of Oncology No. 2011 (2011), pp.1-7.
https://search.emarefa.net/detail/BIM-479866
American Medical Association (AMA)
Masuda, Muneyuki& Wakasaki, Takahiro& Toh, Satoshi& Shimizu, Masahito& Adachi, Seiji. Chemoprevention of Head and Neck Cancer by Green Tea Extract : EGCG—The Role of EGFR Signaling and “Lipid Raft”. Journal of Oncology. 2011. Vol. 2011, no. 2011, pp.1-7.
https://search.emarefa.net/detail/BIM-479866
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-479866