![](/images/graphics-bg.png)
IDH Mutations : Genotype-Phenotype Correlation and Prognostic Impact
Joint Authors
Ciccarino, Pietro
Desestret, Virginie
Labussière, Marianne
Wang, Xiao-Wei
Rossetto, Marta
Gleize, Vincent
Mokhtari, Karima
Sanson, Marc
Boisselier, Blandine
Marie, Yannick
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-04-30
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
IDH1/2 mutation is the most frequent genomic alteration found in gliomas, affecting 40% of these tumors and is one of the earliest alterations occurring in gliomagenesis.
We investigated a series of 1305 gliomas and showed that IDH mutation is almost constant in 1p19q codeleted tumors.
We found that the distribution of IDH1R132H, IDH1nonR132H, and IDH2 mutations differed between astrocytic, mixed, and oligodendroglial tumors, with an overrepresentation of IDH2 mutations in oligodendroglial phenotype and an overrepresentation of IDH1nonR132H in astrocytic tumors.
We stratified grade II and grade III gliomas according to the codeletion of 1p19q and IDH mutation to define three distinct prognostic subgroups: 1p19q and IDH mutated, IDH mutated—which contains mostly TP53 mutated tumors, and none of these alterations.
We confirmed that IDH mutation with a hazard ratio = 0.358 is an independent prognostic factor of good outcome.
These data refine current knowledge on IDH mutation prognostic impact and genotype-phenotype associations.
American Psychological Association (APA)
Wang, Xiao-Wei& Ciccarino, Pietro& Rossetto, Marta& Boisselier, Blandine& Marie, Yannick& Desestret, Virginie…[et al.]. 2014. IDH Mutations : Genotype-Phenotype Correlation and Prognostic Impact. BioMed Research International،Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-479874
Modern Language Association (MLA)
Wang, Xiao-Wei…[et al.]. IDH Mutations : Genotype-Phenotype Correlation and Prognostic Impact. BioMed Research International No. 2014 (2014), pp.1-7.
https://search.emarefa.net/detail/BIM-479874
American Medical Association (AMA)
Wang, Xiao-Wei& Ciccarino, Pietro& Rossetto, Marta& Boisselier, Blandine& Marie, Yannick& Desestret, Virginie…[et al.]. IDH Mutations : Genotype-Phenotype Correlation and Prognostic Impact. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-479874
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-479874