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Joint Assessment of Intended and Unintended Effects of Medications : An Example Using Vascular Endothelial Growth Factor Inhibitors for Neovascular Age-Related Macular Degeneration
Joint Authors
Pleil, Andreas
Levy, Adrian R.
Davie, Alison
Javitt, Jonathan
Briggs, Andrew
Szabo, Shelagh
Zlateva, Gergana
Source
Issue
Vol. 2009, Issue 2009 (31 Dec. 2009), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-02-16
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Objective.
To estimate the net health benefits of pegaptanib and ranibizumab by considering the impact of visual acuity and unintended effects (cardiovascular and hemorrhagic events) on quality-of-life among persons with neovascular age-related macular degeneration.
Methods.
We designed a probabilistic decision-analytic model using published data.
It employed 17 visual health states and three for unintended effects.
We calculated incremental net health benefits by subtracting the harms of each medication from the benefit using the quality-adjusted life year (QALY).
Results.
In a hypothetical cohort of 1,000 75-year olds with new-onset bilateral age-related macular degeneration followed for ten years, the mean QALYs per patient is 3.7 for usual care, 4.2 for pegaptanib, and 4.3 for ranibizumab.
Net benefits decline with increasing baseline rates of unintended effects.
Interpretation.
Net health benefits present a quantitative, potentially useful tool to assist patients and ophthalmologists in balancing the benefits and harms of interventions for age-related macular degeneration.
American Psychological Association (APA)
Levy, Adrian R.& Szabo, Shelagh& Briggs, Andrew& Pleil, Andreas& Davie, Alison& Zlateva, Gergana…[et al.]. 2010. Joint Assessment of Intended and Unintended Effects of Medications : An Example Using Vascular Endothelial Growth Factor Inhibitors for Neovascular Age-Related Macular Degeneration. Journal of Ophthalmology،Vol. 2009, no. 2009, pp.1-9.
https://search.emarefa.net/detail/BIM-479891
Modern Language Association (MLA)
Levy, Adrian R.…[et al.]. Joint Assessment of Intended and Unintended Effects of Medications : An Example Using Vascular Endothelial Growth Factor Inhibitors for Neovascular Age-Related Macular Degeneration. Journal of Ophthalmology No. 2009 (2009), pp.1-9.
https://search.emarefa.net/detail/BIM-479891
American Medical Association (AMA)
Levy, Adrian R.& Szabo, Shelagh& Briggs, Andrew& Pleil, Andreas& Davie, Alison& Zlateva, Gergana…[et al.]. Joint Assessment of Intended and Unintended Effects of Medications : An Example Using Vascular Endothelial Growth Factor Inhibitors for Neovascular Age-Related Macular Degeneration. Journal of Ophthalmology. 2010. Vol. 2009, no. 2009, pp.1-9.
https://search.emarefa.net/detail/BIM-479891
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-479891