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Nucleic Acid Aptamers : Research Tools in Disease Diagnostics and Therapeutics
Joint Authors
Santosh, Baby
Yadava, Pramod K.
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-06-22
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Aptamers are short sequences of nucleic acid (DNA or RNA) or peptide molecules which adopt a conformation and bind cognate ligands with high affinity and specificity in a manner akin to antibody-antigen interactions.
It has been globally acknowledged that aptamers promise a plethora of diagnostic and therapeutic applications.
Although use of nucleic acid aptamers as targeted therapeutics or mediators of targeted drug delivery is a relatively new avenue of research, one aptamer-based drug “Macugen” is FDA approved and a series of aptamer-based drugs are in clinical pipelines.
The present review discusses the aspects of design, unique properties, applications, and development of different aptamers to aid in cancer diagnosis, prevention, and/or treatment under defined conditions.
American Psychological Association (APA)
Santosh, Baby& Yadava, Pramod K.. 2014. Nucleic Acid Aptamers : Research Tools in Disease Diagnostics and Therapeutics. BioMed Research International،Vol. 2014, no. 2014, pp.1-13.
https://search.emarefa.net/detail/BIM-479893
Modern Language Association (MLA)
Santosh, Baby& Yadava, Pramod K.. Nucleic Acid Aptamers : Research Tools in Disease Diagnostics and Therapeutics. BioMed Research International No. 2014 (2014), pp.1-13.
https://search.emarefa.net/detail/BIM-479893
American Medical Association (AMA)
Santosh, Baby& Yadava, Pramod K.. Nucleic Acid Aptamers : Research Tools in Disease Diagnostics and Therapeutics. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-13.
https://search.emarefa.net/detail/BIM-479893
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-479893