Spermicidal Activity of the Safe Natural Antimicrobial Peptide Subtilosin
Joint Authors
Aroutcheva, Alla A.
Dover, Sara E.
Feathergill, Kenneth A.
Faro, Sebastian
Sutyak, Katia E.
Anderson, Robert A.
Chikindas, Michael L.
Source
Infectious Diseases in Obstetrics and Gynecology
Issue
Vol. 2008, Issue 2008 (31 Dec. 2008), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2008-10-09
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Bacterial vaginosis (BV), a condition affecting millions of women each year, is primarily caused by the gram-variable organism Gardnerella vaginalis.
A number of organisms associated with BV cases have been reported to develop multidrug resistance, leading to the need for alternative therapies.
Previously, we reported the antimicrobial peptide subtilosin has proven antimicrobial activity against G.
vaginalis, but not against the tested healthy vaginal microbiota of lactobacilli.
After conducting tissue sensitivity assays using an ectocervical tissue model, we determined that human cells remained viable after prolonged exposures to partially-purified subtilosin, indicating the compound is safe for human use.
Subtilosin was shown to eliminate the motility and forward progression of human spermatozoa in a dose-dependent manner, and can therefore be considered a general spermicidal agent.
These results suggest subtilosin would be a valuable component in topical personal care products aimed at contraception and BV prophylaxis and treatment.
American Psychological Association (APA)
Sutyak, Katia E.& Anderson, Robert A.& Dover, Sara E.& Feathergill, Kenneth A.& Aroutcheva, Alla A.& Faro, Sebastian…[et al.]. 2008. Spermicidal Activity of the Safe Natural Antimicrobial Peptide Subtilosin. Infectious Diseases in Obstetrics and Gynecology،Vol. 2008, no. 2008, pp.1-6.
https://search.emarefa.net/detail/BIM-479922
Modern Language Association (MLA)
Sutyak, Katia E.…[et al.]. Spermicidal Activity of the Safe Natural Antimicrobial Peptide Subtilosin. Infectious Diseases in Obstetrics and Gynecology No. 2008 (2008), pp.1-6.
https://search.emarefa.net/detail/BIM-479922
American Medical Association (AMA)
Sutyak, Katia E.& Anderson, Robert A.& Dover, Sara E.& Feathergill, Kenneth A.& Aroutcheva, Alla A.& Faro, Sebastian…[et al.]. Spermicidal Activity of the Safe Natural Antimicrobial Peptide Subtilosin. Infectious Diseases in Obstetrics and Gynecology. 2008. Vol. 2008, no. 2008, pp.1-6.
https://search.emarefa.net/detail/BIM-479922
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-479922