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Utility of Vascular Endothelial Growth Factor Inhibitors in the Treatment of Ovarian Cancer : From Concept to Application
Joint Authors
Amini, Afshin
Masoumi Moghaddam, Samar
Pourgholami, Mohammad Hossein
Morris, David Lawson
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-09-26
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Abstract EN
Despite recent advances in the management of ovarian cancer, it remains the most lethal gynecologic malignancy.
Vascular endothelial growth factor (VEGF) has been shown to play a pivotal role in the progression of ovarian cancer leading to the eventual development of malignant ascites.
On this basis, agents rendering VEGF ineffective by neutralizing VEGF (bevacizumab), blocking its receptors (aflibercept), or interfering with the postreceptor signaling pathways (sunitinib) provide us with the rational treatment options.
These agents are generally used in combination with the standard chemotherapeutic drugs.
Here, we discuss the basis of and the logic behind the use of these agents in the treatment of epithelial ovarian cancer, as well as their evaluation in different preclinical and clinical studies.
American Psychological Association (APA)
Amini, Afshin& Masoumi Moghaddam, Samar& Morris, David Lawson& Pourgholami, Mohammad Hossein. 2011. Utility of Vascular Endothelial Growth Factor Inhibitors in the Treatment of Ovarian Cancer : From Concept to Application. Journal of Oncology،Vol. 2012, no. 2012, pp.1-14.
https://search.emarefa.net/detail/BIM-479927
Modern Language Association (MLA)
Amini, Afshin…[et al.]. Utility of Vascular Endothelial Growth Factor Inhibitors in the Treatment of Ovarian Cancer : From Concept to Application. Journal of Oncology No. 2012 (2012), pp.1-14.
https://search.emarefa.net/detail/BIM-479927
American Medical Association (AMA)
Amini, Afshin& Masoumi Moghaddam, Samar& Morris, David Lawson& Pourgholami, Mohammad Hossein. Utility of Vascular Endothelial Growth Factor Inhibitors in the Treatment of Ovarian Cancer : From Concept to Application. Journal of Oncology. 2011. Vol. 2012, no. 2012, pp.1-14.
https://search.emarefa.net/detail/BIM-479927
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-479927