HPV Infection : Immunological Aspects and Their Utility in Future Therapy
Joint Authors
Giannouli, Aikaterini
Creatsas, George
Karountzos, Vasileios
Vatopoulou, Anastasia
Dimopoulos, Konstantinos
Deligeoroglou, Efthymios
Athanasopoulos, Nikolaos
Source
Infectious Diseases in Obstetrics and Gynecology
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-08-20
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
High prevalence and mortality rates of cervical cancer create an imperative need to clarify the uniqueness of HPV (Human Papillomavirus) infection, which serves as the key causative factor in cervical malignancies.
Understanding the immunological details and the microenvironment of the infection can be a useful tool for the development of novel therapeutic interventions.
Chronic infection and progression to carcinogenesis are sustained by immortalization potential of HPV, evasion techniques, and alterations in the microenvironment of the lesion.
Inside the lesion, Toll-like receptors expression becomes irregular; Langerhans cells fail to present the antigens efficiently, tumor-associated macrophages aggregate resulting in an unsuccessful immune response by the host.
HPV products also downregulate the expression of microenvironment components which are necessary for natural-killer cells response and antigen presentation to cytotoxic cells.
Additionally HPV promotes T-helper cell 2 (Th2) and T-regulatory cell phenotypes and reduces Th1 phenotype, leading to suppression of cellular immunity and lesion progression to cancer.
Humoral response after natural infection is inefficient, and neutralizing antibodies are not adequate in many women.
Utilizing this knowledge, new endeavors, such as therapeutic vaccination, aim to stimulate cellular immune response against the virus and alter the milieu of the lesion.
American Psychological Association (APA)
Deligeoroglou, Efthymios& Giannouli, Aikaterini& Athanasopoulos, Nikolaos& Karountzos, Vasileios& Vatopoulou, Anastasia& Dimopoulos, Konstantinos…[et al.]. 2013. HPV Infection : Immunological Aspects and Their Utility in Future Therapy. Infectious Diseases in Obstetrics and Gynecology،Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-479936
Modern Language Association (MLA)
Deligeoroglou, Efthymios…[et al.]. HPV Infection : Immunological Aspects and Their Utility in Future Therapy. Infectious Diseases in Obstetrics and Gynecology No. 2013 (2013), pp.1-9.
https://search.emarefa.net/detail/BIM-479936
American Medical Association (AMA)
Deligeoroglou, Efthymios& Giannouli, Aikaterini& Athanasopoulos, Nikolaos& Karountzos, Vasileios& Vatopoulou, Anastasia& Dimopoulos, Konstantinos…[et al.]. HPV Infection : Immunological Aspects and Their Utility in Future Therapy. Infectious Diseases in Obstetrics and Gynecology. 2013. Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-479936
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-479936