Metabolic Signatures of Kidney Yang Deficiency Syndrome and Protective Effects of Two Herbal Extracts in Rats Using GCTOF MS
Joint Authors
Qiu, Mingfeng
Zhao, Linjing
Yang, Yiting
Lu, Lina
Zou, Haimiao
Xin, Xue
Wu, Hongbing
Liu, Jiajian
Su, Jing
Wei, Runmin
Ma, Chungwah
Chen, Tianlu
Zheng, Xiaojiao
Sun, Wei
Zhao, Aihua
Jia, Wei
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-09-12
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Kidney Yang Deficiency Syndrome (KDS-Yang), a typical condition in Chinese medicine, shares similar clinical signs of the glucocorticoid withdrawal syndrome.
To date, the underlying mechanism of KDS-Yang has been remained unclear, especially at the metabolic level.
In this study, we report a metabolomic profiling study on a classical model of KDS-Yang in rats induced by hydrocortisone injection to characterize the metabolic transformation using gas chromatography/time-of-flight mass spectrometry.
WKY1, a polysaccharide extract from Astragalus membranaceus and Lycium barbarum, and WKY2, an aqueous extract from a similar formula containing Astragalus membranaceus, Lycium barbarum, Morinda officinalis, Taraxacum mongolicum, and Cinnamomum cassia presl, were used separately for protective treatments of KDS-Yang.
The changes of serum metabolic profiles indicated that significant alterations of key metabolic pathways in response to abrupt hydrocortisone perturbation, including decreased energy metabolism (lactic acid, acetylcarnitine), lipid metabolism (free fatty acids, 1-monolinoleoylglycerol, and cholesterol), gut microbiota metabolism (indole-3-propionic acid), biosynthesis of catecholamine (norepinephrine), and elevated alanine metabolism, were attenuated or normalized with different degrees by the pretreatment of WKY1 or WKY2, which is consistent with the observations in which the two herbal agents could ameliorate biochemical markers of serum cortisone, adrenocorticotropic (ACTH), and urine 17-hydroxycorticosteroids (17-OHCS).
American Psychological Association (APA)
Zhao, Linjing& Wu, Hongbing& Qiu, Mingfeng& Sun, Wei& Wei, Runmin& Zheng, Xiaojiao…[et al.]. 2013. Metabolic Signatures of Kidney Yang Deficiency Syndrome and Protective Effects of Two Herbal Extracts in Rats Using GCTOF MS. Evidence-Based Complementary and Alternative Medicine،Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-479947
Modern Language Association (MLA)
Zhao, Linjing…[et al.]. Metabolic Signatures of Kidney Yang Deficiency Syndrome and Protective Effects of Two Herbal Extracts in Rats Using GCTOF MS. Evidence-Based Complementary and Alternative Medicine No. 2013 (2013), pp.1-10.
https://search.emarefa.net/detail/BIM-479947
American Medical Association (AMA)
Zhao, Linjing& Wu, Hongbing& Qiu, Mingfeng& Sun, Wei& Wei, Runmin& Zheng, Xiaojiao…[et al.]. Metabolic Signatures of Kidney Yang Deficiency Syndrome and Protective Effects of Two Herbal Extracts in Rats Using GCTOF MS. Evidence-Based Complementary and Alternative Medicine. 2013. Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-479947
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-479947