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Light Chain Proximal Tubulopathy : Expanding the Pathologic Spectrum with and without Deposition of Crystalline Inclusions
Joint Authors
Sharma, Shree G.
Bonsib, Stephen M.
Gokden, Neriman
Woodruff, Adam B.
Portilla, Didier
Shukla, Ashutosh
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-08-30
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Light chain proximal tubulopathy (LCPT) is an uncommon form of renal disease associated with dysproteinemias.
It is characterized by intracytoplasmic deposition of crystallized mostly kappa monoclonal light chains in proximal tubules (PTs).
Crystals are located within lysosomes by electron microscopy (EM).
Rare lambda LCPT cases without crystals by EM were described.
Retrospectively, we reviewed clinical, light microscopic (LM), immunofluorescence (IF), and EM findings in 9 cases) (8 males, 1 female; mean age 57 years (38–81)) with multiple myeloma.
LM showed abundant cytoplasmic droplets in PT cells in all cases.
Droplets were also present in the podocytes, endothelial and parietal cells in one case.
IF revealed staining of crystals with kappa in 3 and lambda in 6.
EM showed electron dense rectangular, rhomboid, or needle shaped crystals in PT cells in 3 cases (33%), one of which had crystals in podocytes and interstitial cells.
Six lambda LCPT cases showed no crystals by EM (67%).
This may reflect differences in the physicochemical properties of light chains.
The mechanisms of crystal accumulation in these cells and the significance of this finding are unknown.
American Psychological Association (APA)
Sharma, Shree G.& Bonsib, Stephen M.& Portilla, Didier& Shukla, Ashutosh& Woodruff, Adam B.& Gokden, Neriman. 2012. Light Chain Proximal Tubulopathy : Expanding the Pathologic Spectrum with and without Deposition of Crystalline Inclusions. ISRN Pathology،Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-479959
Modern Language Association (MLA)
Sharma, Shree G.…[et al.]. Light Chain Proximal Tubulopathy : Expanding the Pathologic Spectrum with and without Deposition of Crystalline Inclusions. ISRN Pathology No. 2012 (2012), pp.1-6.
https://search.emarefa.net/detail/BIM-479959
American Medical Association (AMA)
Sharma, Shree G.& Bonsib, Stephen M.& Portilla, Didier& Shukla, Ashutosh& Woodruff, Adam B.& Gokden, Neriman. Light Chain Proximal Tubulopathy : Expanding the Pathologic Spectrum with and without Deposition of Crystalline Inclusions. ISRN Pathology. 2012. Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-479959
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-479959