Cinchonine Prevents High-Fat-Diet-Induced Obesity through Downregulation of Adipogenesis and Adipose Inflammation

Joint Authors

Yu, Rina
Park, Taesun
Choi, Miseon
Kim, Sohee
Jung, Sung A.

Source

PPAR Research

Issue

Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-11, 11 p.

Publisher

Hindawi Publishing Corporation

Publication Date

2012-05-16

Country of Publication

Egypt

No. of Pages

11

Main Subjects

Natural & Life Sciences (Multidisciplinary)
Biology

Abstract EN

Cinchonine (C19H22N2O) is a natural compound of Cinchona bark.

Although cinchonine's antiplatelet effect has been reported in the previous study, antiobesity effect of cinchonine has never been studied.

The main objective of this study was to investigate whether cinchonine reduces high-fat-diet- (HFD-) induced adipogenesis and inflammation in the epididymal fat tissues of mice and to explore the underlying mechanisms involved in these reductions.

HFD-fed mice treated with 0.05% dietary cinchonine for 10 weeks had reduced body weight gain (−38%), visceral fat-pad weights (−26%), and plasma levels of triglyceride, free fatty acids, total cholesterol, and glucose compared with mice fed with the HFD.

Moreover, cinchonine significantly reversed HFD-induced downregulations of WNT10b and galanin-mediated signaling molecules and key adipogenic genes in the epididymal adipose tissues of mice.

Cinchonine also attenuated the HFD-induced upregulation of proinflammatory cytokines by inhibiting toll-like-receptor-2- (TLR2-) and TLR4-mediated signaling cascades in the adipose tissue of mice.

Our findings suggest that dietary cinchonine with its effects on adipogenesis and inflammation may have a potential benefit in preventing obesity.

American Psychological Association (APA)

Jung, Sung A.& Choi, Miseon& Kim, Sohee& Yu, Rina& Park, Taesun. 2012. Cinchonine Prevents High-Fat-Diet-Induced Obesity through Downregulation of Adipogenesis and Adipose Inflammation. PPAR Research،Vol. 2012, no. 2012, pp.1-11.
https://search.emarefa.net/detail/BIM-479966

Modern Language Association (MLA)

Jung, Sung A.…[et al.]. Cinchonine Prevents High-Fat-Diet-Induced Obesity through Downregulation of Adipogenesis and Adipose Inflammation. PPAR Research No. 2012 (2012), pp.1-11.
https://search.emarefa.net/detail/BIM-479966

American Medical Association (AMA)

Jung, Sung A.& Choi, Miseon& Kim, Sohee& Yu, Rina& Park, Taesun. Cinchonine Prevents High-Fat-Diet-Induced Obesity through Downregulation of Adipogenesis and Adipose Inflammation. PPAR Research. 2012. Vol. 2012, no. 2012, pp.1-11.
https://search.emarefa.net/detail/BIM-479966

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references

Record ID

BIM-479966