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Cinchonine Prevents High-Fat-Diet-Induced Obesity through Downregulation of Adipogenesis and Adipose Inflammation
Joint Authors
Yu, Rina
Park, Taesun
Choi, Miseon
Kim, Sohee
Jung, Sung A.
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-05-16
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Biology
Abstract EN
Cinchonine (C19H22N2O) is a natural compound of Cinchona bark.
Although cinchonine's antiplatelet effect has been reported in the previous study, antiobesity effect of cinchonine has never been studied.
The main objective of this study was to investigate whether cinchonine reduces high-fat-diet- (HFD-) induced adipogenesis and inflammation in the epididymal fat tissues of mice and to explore the underlying mechanisms involved in these reductions.
HFD-fed mice treated with 0.05% dietary cinchonine for 10 weeks had reduced body weight gain (−38%), visceral fat-pad weights (−26%), and plasma levels of triglyceride, free fatty acids, total cholesterol, and glucose compared with mice fed with the HFD.
Moreover, cinchonine significantly reversed HFD-induced downregulations of WNT10b and galanin-mediated signaling molecules and key adipogenic genes in the epididymal adipose tissues of mice.
Cinchonine also attenuated the HFD-induced upregulation of proinflammatory cytokines by inhibiting toll-like-receptor-2- (TLR2-) and TLR4-mediated signaling cascades in the adipose tissue of mice.
Our findings suggest that dietary cinchonine with its effects on adipogenesis and inflammation may have a potential benefit in preventing obesity.
American Psychological Association (APA)
Jung, Sung A.& Choi, Miseon& Kim, Sohee& Yu, Rina& Park, Taesun. 2012. Cinchonine Prevents High-Fat-Diet-Induced Obesity through Downregulation of Adipogenesis and Adipose Inflammation. PPAR Research،Vol. 2012, no. 2012, pp.1-11.
https://search.emarefa.net/detail/BIM-479966
Modern Language Association (MLA)
Jung, Sung A.…[et al.]. Cinchonine Prevents High-Fat-Diet-Induced Obesity through Downregulation of Adipogenesis and Adipose Inflammation. PPAR Research No. 2012 (2012), pp.1-11.
https://search.emarefa.net/detail/BIM-479966
American Medical Association (AMA)
Jung, Sung A.& Choi, Miseon& Kim, Sohee& Yu, Rina& Park, Taesun. Cinchonine Prevents High-Fat-Diet-Induced Obesity through Downregulation of Adipogenesis and Adipose Inflammation. PPAR Research. 2012. Vol. 2012, no. 2012, pp.1-11.
https://search.emarefa.net/detail/BIM-479966
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-479966