Philicity and Fugality Scales for Organic Reactions
Joint Authors
Ormazábal-Toledo, Rodrigo
Contreras, Renato
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-08-18
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Theoretical scales of reactivity and selectivity are important tools to explain and to predict reactivity patterns, including reaction mechanisms.
The main achievement of these efforts has been the incorporation of such concepts in advanced texts of organic chemistry.
In this way, the modern organic chemistry language has become more quantitative, making the classification of organic reactions an easier task.
The reactivity scales are also useful to set up a number of empirical rules that help in rationalizing and in some cases anticipating the possible reaction mechanisms that can be operative in a given organic reaction.
In this review, we intend to give a brief but complete account on this matter, introducing the conceptual basis that leads to the definition of reactivity indices amenable to build up quantitative models of reactivity in organic reactions.
The emphasis is put on two basic concepts describing electron-rich and electron-deficient systems, namely, nucleophile and electrophiles.
We then show that the regional nucleophilicity and electrophilicity become the natural descriptors of electrofugality and nucleofugality, respectively.
In this way, we obtain a closed body of concepts that suffices to describe electron releasing and electron accepting molecules together with the description of permanent and leaving groups in addition, nucleophilic substitution and elimination reactions.
American Psychological Association (APA)
Ormazábal-Toledo, Rodrigo& Contreras, Renato. 2014. Philicity and Fugality Scales for Organic Reactions. Advances in Chemistry،Vol. 2014, no. 2014, pp.1-13.
https://search.emarefa.net/detail/BIM-480005
Modern Language Association (MLA)
Ormazábal-Toledo, Rodrigo& Contreras, Renato. Philicity and Fugality Scales for Organic Reactions. Advances in Chemistry No. 2014 (2014), pp.1-13.
https://search.emarefa.net/detail/BIM-480005
American Medical Association (AMA)
Ormazábal-Toledo, Rodrigo& Contreras, Renato. Philicity and Fugality Scales for Organic Reactions. Advances in Chemistry. 2014. Vol. 2014, no. 2014, pp.1-13.
https://search.emarefa.net/detail/BIM-480005
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-480005