![](/images/graphics-bg.png)
Prognostic Impacts of Hypoxic Markers in Soft Tissue Sarcoma
Joint Authors
Andersen, Sigve
Bremnes, Roy M.
Kilvaer, Thomas Karsten
Busund, Lill-Tove
Valkov, Andrej
Smeland, Eivind
Donnem, Tom
Sorbye, Sveinung
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-02-20
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Background.
We aimed to explore the prognostic impact of the hypoxia-induced factors (HIFαs) 1 and 2, the metabolic HIF-regulated glucose transporter GLUT-1, and carbonic anhydrase IX (CAIX) in non-gastrointestinal stromal tumor soft tissue sarcomas (non-GIST STS).
Methods.
Duplicate cores with viable tumor tissue from 206 patients with non-GIST STS were obtained and tissue microarrays were constructed.
Immunohistochemistry (IHC) was used to evaluate expression of hypoxic markers.
Results.
In univariate analyses, GLUT-1 (P<0.001) and HIF-2α (P=0.032) expression correlated significantly with a poor disease-specific survival (DSS).
In the multivariate analysis, however, only high expression of GLUT-1 (HR 1.7, CI 95% 1.1–2.7, P=0.021) was a significant independent prognostic indicator of poor DSS.
Conclusion.
GLUT-1 is a significant independent negative prognostic factor in non-GIST STS.
American Psychological Association (APA)
Smeland, Eivind& Kilvaer, Thomas Karsten& Sorbye, Sveinung& Valkov, Andrej& Andersen, Sigve& Bremnes, Roy M.…[et al.]. 2012. Prognostic Impacts of Hypoxic Markers in Soft Tissue Sarcoma. Sarcoma،Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-480014
Modern Language Association (MLA)
Smeland, Eivind…[et al.]. Prognostic Impacts of Hypoxic Markers in Soft Tissue Sarcoma. Sarcoma No. 2012 (2012), pp.1-10.
https://search.emarefa.net/detail/BIM-480014
American Medical Association (AMA)
Smeland, Eivind& Kilvaer, Thomas Karsten& Sorbye, Sveinung& Valkov, Andrej& Andersen, Sigve& Bremnes, Roy M.…[et al.]. Prognostic Impacts of Hypoxic Markers in Soft Tissue Sarcoma. Sarcoma. 2012. Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-480014
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-480014